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Tchem
BCL2A1
Bcl-2-related protein A1

Protein Classes
Protein Summary
Description
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity). This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, whi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267953
  • ENSP00000267953
  • ENSG00000140379
  • ENST00000335661
  • ENSP00000335250

Symbol
  • BCL2L5
  • BFL1
  • GRS
  • HBPA1
  • GRS
  • ACC1
  • ACC2
  • BFL1
  • ACC-1
  • ACC-2
  • HBPA1
  • BCL2L5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
protein domain
0.73
transcription factor perturbation
0.68
PubMedID
0.67
biological term
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1111.19   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1111.19   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
5
6
98.8
eosinophil count
5
8
8
98.5
monocyte count
3
3
3
96.7
eosinophil percentage of leukocytes
2
4
4
95.5
granulocyte percentage of myeloid white cells
1
2
2
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
6
98.8
eosinophil count
8
98.5
monocyte count
3
96.7
eosinophil percentage of leukocytes
4
95.5
granulocyte percentage of myeloid white cells
2
89.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 related protein A1
VGNC:6578
100610077
Macaque
BCL2 related protein A1
712571
Mouse
MGI:102687
12044
Rat
RGD:620621
170929
Dog
BCL2 related protein A1
488770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 related protein A1
Macaque
BCL2 related protein A1
Mouse
Rat
Dog
BCL2 related protein A1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16548-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Acute myeloid leukemia
KEGG
Transcriptional misregulation in cancer
KEGG
Apoptosis
KEGG
NF-kappa B signaling pathway
Name
Explore in Pharos
Explore in Source
Acute myeloid leukemia
Transcriptional misregulation in cancer
Apoptosis
NF-kappa B signaling pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (153)
1 – 10 of 153
BCL2L11
Tchem
Novelty:  0.00055914
Score:  0.989
Data Source:  STRINGDB
BBC3
Tbio
Novelty:  0.00773944
Score:  0.976
Data Source:  STRINGDB
PMAIP1
Tbio
Novelty:  0.00198406
Score:  0.976
Data Source:  STRINGDB
BBC3
Tbio
Novelty:  0.00773944
Score:  0.976
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.956
Data Source:  STRINGDB
BID
Tbio
Novelty:  0.01264688
Score:  0.954
Data Source:  STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
Score:  0.946
Data Source:  STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.941
Data Source:  STRINGDB
BAK1
Tbio
Novelty:  0.00381053
Score:  0.938
Data Source:  STRINGDB
MCL1
Tchem
Novelty:  0.00046181
Score:  0.928
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1111.19

PubMed score by year
PubTator Score  1142.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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