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Tbio
CDC37
Hsp90 co-chaperone Cdc37

Protein Summary
Description
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206). The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222005
  • ENSP00000222005
  • ENSG00000105401

Symbol
  • CDC37A
  • P50CDC37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.93
transcription factor binding site profile
0.79
histone modification site profile
0.71
protein complex
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 508   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
77.8
1
1
0
1.1
63.3
1
1
0
1.1
48
leukocyte count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
77.8
0
1.1
63.3
0
1.1
48
leukocyte count
1
30.2
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (77)
Constitutive Signaling by EGFRvIII (R-HSA-5637810)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by EGFRvIII
Reactome
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of ERBB2 signaling
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by EGFRvIII
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Disease
Diseases of signal transduction
Downregulation of ERBB2 signaling
Gene Ontology Terms (23)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (171)
1 – 10 of 171
CDK9
Tchem
Family: Kinase
Novelty: 0.00210218
p_int: 0.997498404
p_ni: 0.002501596
Score: 0.693
Data Source: BioPlex,STRINGDB
STK35
Tchem
Family: Kinase
Novelty: 0.19556072
p_int: 0.997028957
p_ni: 0.002971043
Score: 0.18
Data Source: BioPlex,STRINGDB
CDK11A
Tchem
Family: Kinase
Novelty: 0.02312993
p_int: 0.992823392
p_ni: 0.007176608
Score: 0.373
Data Source: BioPlex,STRINGDB
AKT3
Tchem
Family: Kinase
Novelty: 0.00308931
p_int: 0.986072309
p_ni: 0.013927691
Score: 0.758
Data Source: BioPlex,STRINGDB
RPS6KA4
Tchem
Family: Kinase
Novelty: 0.05213255
p_int: 0.974547246
p_ni: 0.025452754
Data Source: BioPlex
PDIK1L
Tdark
Family: Kinase
Novelty: 0.4630487
p_int: 0.970513978
p_ni: 0.029486022
Score: 0.161
Data Source: BioPlex,STRINGDB
BTK
Tclin
Family: Kinase
Novelty: 0.00050747
p_int: 0.94713995
p_ni: 0.05286005
Score: 0.239
Data Source: BioPlex,STRINGDB
PRKCE
Tchem
Family: Kinase
Novelty: 0.00890161
p_int: 0.933800939
p_ni: 0.066199061
Score: 0.15
Data Source: BioPlex,STRINGDB
PCBP1
Tbio
Novelty: 0.00906713
p_int: 0.919020572
p_ni: 0.080979428
Score: 0.267
Data Source: BioPlex,STRINGDB
CLK3
Tchem
Family: Kinase
Novelty: 0.03466191
p_int: 0.915436053
p_ni: 0.084563947
Score: 0.246
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.00

PubMed score by year
PubTator Score  103.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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