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Tdark
MRPL23
39S ribosomal protein L23, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381519
  • ENSP00000370930
  • ENSG00000214026
  • ENST00000397298
  • ENSP00000380466

Symbol
  • L23MRP
  • RPL23L
  • RPL23
  • L23MRP
  • RPL23L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
cellular component
0.88
transcription factor binding site profile
0.75
transcription factor
0.69
phenotype
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.82   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.82   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (176)
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.999561746
p_ni:  0.000438254
Score:  0.879
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.99628467
p_ni:  0.003715331
Score:  0.961
Data Source:  BioPlex,STRINGDB
NARS2
Tbio
Family:  Enzyme
Novelty:  0.01879317
p_int:  0.989461017
p_ni:  0.010533499
p_wrong:  0.000005484
Data Source:  BioPlex
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.984997008
p_ni:  0.015002992
Score:  0.922
Data Source:  BioPlex,STRINGDB
MRPL28
Tdark
Novelty:  0.23845162
p_int:  0.979257434
p_ni:  0.020742566
Score:  0.965
Data Source:  BioPlex,STRINGDB
MRPL51
Tdark
Novelty:  0.24304433
p_int:  0.968434321
p_ni:  0.026346643
p_wrong:  0.005219036
Score:  0.948
Data Source:  BioPlex,STRINGDB
MRPL32
Tdark
Novelty:  0.58976136
p_int:  0.966949308
p_ni:  0.030428286
p_wrong:  0.002622406
Score:  0.956
Data Source:  BioPlex,STRINGDB
ARFGEF2
Tbio
Novelty:  0.05568966
p_int:  0.951815339
p_ni:  0.04818466
Data Source:  BioPlex
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.949097277
p_ni:  0.050554633
p_wrong:  0.000348091
Score:  0.866
Data Source:  BioPlex,STRINGDB
MRPL9
Tdark
Novelty:  0.43920695
p_int:  0.94444829
p_ni:  0.05555171
Score:  0.917
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
89.5
monocyte count
2
1
2
85.4
monocyte percentage of leukocytes
2
1
2
82.6
1
3
3
82
Diuretic use measurement
1
1
1
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
89.5
monocyte count
2
85.4
monocyte percentage of leukocytes
2
82.6
3
82
Diuretic use measurement
1
80.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L23
VGNC:12610
450950
Macaque
mitochondrial ribosomal protein L23
704210
Mouse
MGI:1196612
19935
Rat
RGD:68343
64360
Dog
mitochondrial ribosomal protein L23
483663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L23
Macaque
mitochondrial ribosomal protein L23
Mouse
Rat
Dog
mitochondrial ribosomal protein L23
Publication Statistics
PubMed Score 3.82
PubMed score by year
PubTator Score 3.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title