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Tbio
HLF
Hepatic leukemia factor

Protein Summary
Description
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226067
  • ENSP00000226067
  • ENSG00000108924
  • ENST00000430986
  • ENSP00000402496
  • ENST00000573945
  • ENSP00000460296
  • ENST00000575345
  • ENSP00000460572
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
PubMedID
0.94
microRNA
0.72
transcription factor binding site profile
0.68
histone modification site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.28   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.28   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
TLK1
Tchem
Family:  Kinase
Novelty:  0.0342719
p_int:  0.979793251
p_ni:  0.017445324
p_wrong:  0.002761425
Score:  0.485
Data Source:  BioPlex,STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.875
Data Source:  STRINGDB
SRPX2
Tbio
Novelty:  0.01298081
Score:  0.742
Data Source:  STRINGDB
ANXA8
Tbio
Novelty:  0.00056216
Score:  0.741
Data Source:  STRINGDB
TLE2
Tbio
Novelty:  0.03922169
Score:  0.728
Data Source:  STRINGDB
AES
Tbio
Novelty:  0.00818499
Score:  0.712
Data Source:  STRINGDB
TLE6
Tbio
Novelty:  0.07734594
Score:  0.711
Data Source:  STRINGDB
NPAS2
Tbio
Family:  TF
Novelty:  0.00728451
Score:  0.688
Data Source:  STRINGDB
CRY1
Tchem
Novelty:  0.00116593
Score:  0.676
Data Source:  STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
3
6
95.9
mean corpuscular hemoglobin concentration
1
1
1
58.4
uric acid measurement
1
1
1
53.7
IGF-1 measurement
1
1
1
49.5
hemoglobin measurement
2
1
2
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
95.9
mean corpuscular hemoglobin concentration
1
58.4
uric acid measurement
1
53.7
IGF-1 measurement
1
49.5
hemoglobin measurement
2
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HLF, PAR bZIP transcription factor
VGNC:10210
455140
Macaque
HLF, PAR bZIP transcription factor
706623
Mouse
MGI:96108
217082
Rat
RGD:1582828
690286
Dog
HLF, PAR bZIP transcription factor
VGNC:49094
609564
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HLF, PAR bZIP transcription factor
Macaque
HLF, PAR bZIP transcription factor
Mouse
Rat
Dog
HLF, PAR bZIP transcription factor
Publication Statistics
PubMed Score 31.28
PubMed score by year
PubTator Score 218.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title