Protein Summary
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
- ENST00000008527
- ENSP00000008527
- ENSG00000008405
- PHLL1
- DSPD
- PHLL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
biological process | 0.98 | ||
transcription factor binding site profile | 0.9 | ||
kinase perturbation | 0.71 | ||
cellular component | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 897.43 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 255 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 897.43 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 255 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (109)
CRY2
Novelty: 0.00156961
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
FBXL3
Novelty: 0.05042679
p_int: 0.999999998
p_ni: 2e-9
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
PER1
Novelty: 0.01290576
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CSNK1E
Family: Kinase
Novelty: 0.00891859
p_int: 0.999999606
p_ni: 3.94e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RGS20
Novelty: 0.04087618
p_int: 0.999998002
p_ni: 0.000001997
p_wrong: 1e-9
Score: 0.182
Data Source: BioPlex,STRINGDB
SKP1
Family: Enzyme
Novelty: 0.00149739
p_int: 0.99999407
p_ni: 0.00000593
Score: 0.563
Data Source: BioPlex,STRINGDB
TEKT4
Novelty: 0.05559086
p_int: 0.999990895
p_ni: 0.000009105
Score: 0.552
Data Source: BioPlex,STRINGDB
RETNLB
Novelty: 0.00777842
p_int: 0.999990451
p_ni: 0.000009525
p_wrong: 2.4e-8
Data Source: BioPlex
CSNK1D
Family: Kinase
Novelty: 0.00896935
p_int: 0.999979755
p_ni: 0.000020245
Score: 0.993
Data Source: BioPlex,STRINGDB
AP2M1
Novelty: 0.00769368
p_int: 0.999956739
p_ni: 0.00004326
p_wrong: 1e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (1)
KEGG (1)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Circadian Clock | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Circadian Clock | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (9)
Components (2)
Processes (20)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 2 | 2 | 1 | 8.6 | 80.2 | ||||
chronotype measurement | 3 | 2 | 2 | 1 | 71.1 | ||||
bone density | 1 | 2 | 2 | 58.2 | |||||
heel bone mineral density | 2 | 2 | 2 | 52.7 | |||||
femoral neck bone mineral density | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 8.6 | 80.2 | ||||
chronotype measurement | 2 | 1 | 71.1 | ||||
bone density | 2 | 58.2 | |||||
heel bone mineral density | 2 | 52.7 | |||||
femoral neck bone mineral density | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cryptochrome circadian regulator 1 | VGNC:5348 | 452205 | |||||
Macaque | cryptochrome circadian regulator 1 | 703752 | ||||||
Mouse | MGI:1270841 | 12952 | ||||||
Rat | RGD:735083 | 299691 | ||||||
Dog | cryptochrome circadian regulator 1 | VGNC:39633 | 474528 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cryptochrome circadian regulator 1 | |||||
Macaque | cryptochrome circadian regulator 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cryptochrome circadian regulator 1 | |||||
Publication Statistics
PubMed Score 897.43
PubMed score by year
PubTator Score 165.83
PubTator score by year
Related Publications
Text Mined References (83)
GeneRif Annotations (49)
Items per page:
0 of 0
PMID | Year | Title |
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