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Tchem
CRY1
Cryptochrome-1

Protein Summary
Description
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000008527
  • ENSP00000008527
  • ENSG00000008405

Symbol
  • PHLL1
  • DSPD
  • PHLL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.98
transcription factor binding site profile
0.9
kinase perturbation
0.71
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 897.43   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 897.43   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
KL044
Rendered image for KL044
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8.6
80.2
chronotype measurement
3
2
2
1
71.1
bone density
1
2
2
58.2
heel bone mineral density
2
2
2
52.7
femoral neck bone mineral density
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8.6
80.2
chronotype measurement
2
1
71.1
bone density
2
58.2
heel bone mineral density
2
52.7
femoral neck bone mineral density
1
35
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cryptochrome circadian regulator 1
VGNC:5348
452205
Macaque
cryptochrome circadian regulator 1
703752
Mouse
MGI:1270841
12952
Rat
RGD:735083
299691
Dog
cryptochrome circadian regulator 1
VGNC:39633
474528
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cryptochrome circadian regulator 1
Macaque
cryptochrome circadian regulator 1
Mouse
Rat
Dog
cryptochrome circadian regulator 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16526-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Circadian Clock
Gene Ontology Terms (31)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (109)
1 – 10 of 109
CRY2
Tbio
Novelty:  0.00156961
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
FBXL3
Tbio
Novelty:  0.05042679
p_int:  0.999999998
p_ni:  2e-9
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
PER1
Tbio
Novelty:  0.01290576
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
p_int:  0.999999606
p_ni:  3.94e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999998002
p_ni:  0.000001997
p_wrong:  1e-9
Score:  0.182
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.99999407
p_ni:  0.00000593
Score:  0.563
Data Source:  BioPlex,STRINGDB
TEKT4
Tbio
Novelty:  0.05559086
p_int:  0.999990895
p_ni:  0.000009105
Score:  0.552
Data Source:  BioPlex,STRINGDB
RETNLB
Tbio
Novelty:  0.00777842
p_int:  0.999990451
p_ni:  0.000009525
p_wrong:  2.4e-8
Data Source:  BioPlex
CSNK1D
Tchem
Family:  Kinase
Novelty:  0.00896935
p_int:  0.999979755
p_ni:  0.000020245
Score:  0.993
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999956739
p_ni:  0.00004326
p_wrong:  1e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  897.43

PubMed score by year
PubTator Score  165.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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