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Tbio
BATF
Basic leucine zipper transcriptional factor ATF-like

Protein Summary
Description
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286639
  • ENSP00000286639
  • ENSG00000156127

Symbol
  • SFA2
  • B-ATF
  • BATF1
  • SFA-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
tissue sample
0.72
disease perturbation
0.68
phenotype
0.61
PubMedID
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.44   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 383   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.44   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
77.2
1
1
0
1.1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
77.2
0
1.1
2.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper ATF-like transcription factor
VGNC:8194
453049
Macaque
basic leucine zipper ATF-like transcription factor
702646
Mouse
MGI:1859147
53314
Rat
RGD:1304923
299206
Dog
basic leucine zipper ATF-like transcription factor
VGNC:38385
611951
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic leucine zipper ATF-like transcription factor
Macaque
basic leucine zipper ATF-like transcription factor
Mouse
Rat
Dog
basic leucine zipper ATF-like transcription factor
Pathways (56)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (97)
1 – 10 of 97
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.974
Data Source: STRINGDB
JUNB
Tbio
Family: TF
Novelty: 0.00841656
Score: 0.955
Data Source: STRINGDB
STAT6
Tchem
Family: TF
Novelty: 0.00096732
Score: 0.948
Data Source: STRINGDB
IRF4
Tbio
Family: TF
Novelty: 0.00192973
Score: 0.912
Data Source: STRINGDB
JUND
Tbio
Family: TF
Novelty: 0.00277701
Score: 0.843
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.824
Data Source: STRINGDB
IL17A
Tclin
Novelty: 0.00011583
Score: 0.753
Data Source: STRINGDB
TBX21
Tbio
Family: TF
Novelty: 0.0009971
Score: 0.706
Data Source: STRINGDB
CCRL2
Tchem
Family: GPCR
Novelty: 0.00294533
Score: 0.7
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00005852
Score: 0.691
Data Source: STRINGDB
Publication Statistics
PubMed Score  122.44

PubMed score by year
PubTator Score  38.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer