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Tbio
RPE65
Retinoid isomerohydrolase

Protein Summary
Description
Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity). The protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262340
  • ENSP00000262340
  • ENSG00000116745

Symbol
  • p63
  • BCO3
  • LCA2
  • RP20
  • rd12
  • mRPE65
  • sRPE65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
cell type or tissue
0.65
biological process
0.59
cell line
0.56
phenotype
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 719.14   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 719.14   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
facial morphology measurement
1
1
2
33.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
facial morphology measurement
2
33.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RPE65, retinoid isomerohydrolase
VGNC:12954
744567
Macaque
RPE65, retinoid isomerohydrolase
701764
Mouse
MGI:98001
19892
Rat
RGD:621396
89826
Dog
RPE65, retinoid isomerohydrolase
VGNC:45708
403803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RPE65, retinoid isomerohydrolase
Macaque
RPE65, retinoid isomerohydrolase
Mouse
Rat
Dog
RPE65, retinoid isomerohydrolase
Pathways (83)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
The canonical retinoid cycle in rods (twilight vision)
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
The canonical retinoid cycle in rods (twilight vision)
Gene Ontology Terms (27)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
AgBase
Inferred from Sequence or structural Similarity (ISS)
AgBase
Inferred from Sequence or structural Similarity (ISS)
AgBase
Inferred from Sequence or structural Similarity (ISS)
AgBase
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (127)
1 – 10 of 127
ZMYM2
Tbio
Novelty: 0.0258698
p_int: 0.919499205
p_ni: 0.080500795
Score: 0.214
Data Source: BioPlex,STRINGDB
CCT6B
Tdark
Novelty: 0.28933315
p_int: 0.874090978
p_ni: 0.125909022
Score: 0.537
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.791668018
p_ni: 0.208331982
Score: 0.268
Data Source: BioPlex,STRINGDB
RLBP1
Tbio
Novelty: 0.00526176
Score: 0.988
Data Source: STRINGDB
LRAT
Tbio
Family: Enzyme
Novelty: 0.00593203
Score: 0.988
Data Source: STRINGDB
RDH5
Tbio
Family: Enzyme
Novelty: 0.0111079
Score: 0.982
Data Source: STRINGDB
RDH10
Tbio
Family: Enzyme
Novelty: 0.03049914
Score: 0.955
Data Source: STRINGDB
RDH11
Tbio
Family: Enzyme
Novelty: 0.02758936
Score: 0.953
Data Source: STRINGDB
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
Score: 0.94
Data Source: STRINGDB
AWAT2
Tbio
Family: Enzyme
Novelty: 0.00986244
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  719.14

PubMed score by year
PubTator Score  302.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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