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Tchem
ASIC2
Acid-sensing ion channel 2

Protein Summary
Description
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identifi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225823
  • ENSP00000225823
  • ENSG00000108684
  • ENST00000359872
  • ENSP00000352934

Symbol
  • ACCN
  • ACCN1
  • BNAC1
  • MDEG
  • ACCN
  • BNC1
  • MDEG
  • ACCN1
  • BNaC1
  • ASIC2a
  • hBNaC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.9
biological process
0.86
transcription factor
0.71
phenotype
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390.61   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390.61   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
96.1
body mass index
1
2
2
80.3
self reported educational attainment
1
1
1
74.9
cognitive function measurement
1
1
1
63.6
puberty onset measurement
1
1
1
41.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
96.1
body mass index
2
80.3
self reported educational attainment
1
74.9
cognitive function measurement
1
63.6
puberty onset measurement
1
41.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid sensing ion channel subunit 2
VGNC:51633
748244
Macaque
acid sensing ion channel subunit 2
718204
Mouse
MGI:1100867
11418
Rat
RGD:2017
25364
Dog
acid sensing ion channel subunit 2
VGNC:38178
491150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid sensing ion channel subunit 2
Macaque
acid sensing ion channel subunit 2
Mouse
Rat
Dog
acid sensing ion channel subunit 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16515-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (46)
1 – 10 of 46
ASIC1
Tchem
Family: IC
Novelty: 0.00705323
p_int: 0.999999997
p_wrong: 3e-9
Score: 0.607
Data Source: BioPlex,STRINGDB
STOM
Tbio
Novelty: 0.00459891
Score: 0.97
Data Source: STRINGDB
STOML3
Tbio
Novelty: 0.0587281
Score: 0.956
Data Source: Reactome,STRINGDB
PICK1
Tbio
Novelty: 0.0058265
Score: 0.861
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.801
Data Source: STRINGDB
TRPV1
Tclin
Family: IC
Novelty: 0.00039493
Score: 0.67
Data Source: STRINGDB
TRPA1
Tclin
Family: IC
Novelty: 0.00093648
Score: 0.597
Data Source: STRINGDB
TRPV4
Tchem
Family: IC
Novelty: 0.00111193
Score: 0.539
Data Source: STRINGDB
P2RX3
Tchem
Family: IC
Novelty: 0.00203167
Score: 0.51
Data Source: STRINGDB
TFCP2
Tbio
Family: TF
Novelty: 0.00687548
Score: 0.509
Data Source: STRINGDB
Publication Statistics
PubMed Score  390.61

PubMed score by year
PubTator Score  77.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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