Tchem ASIC2 Acid-sensing ion channel 2

Protein Summary

Description

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q16515
• E9PBX2
• Q13553
• Q6DJU1
• Q8N3E2
• ASIC2

Gene Name

• ASIC2

Ensembl ID

• ENST00000225823
• ENSP00000225823
• ENSG00000108684
• ENST00000359872
• ENSP00000352934

Symbol

• ACCN
• ACCN1
• BNAC1
• MDEG
• ACCN
• BNC1
• MDEG
• ACCN1
• BNaC1
• ASIC2a
• hBNaC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
molecular function	0.9
biological process	0.86
transcription factor	0.71
phenotype	0.69

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Acid-sensing Ion Channel 2

DTO Classes

Protein / Ion Channel / Amiloride-sensitive Sodium Channel Family / Acid-sensing Ion Channel 2 (Asic2) Subfamily / Acid-sensing Ion Channel 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.01   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.01   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2