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Tbio
TAF12
Transcription initiation factor TFIID subunit 12

Protein Summary
Description
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263974
  • ENSP00000263974
  • ENSG00000120656
  • ENST00000373824
  • ENSP00000362930

Symbol
  • TAF15
  • TAF2J
  • TAFII20
  • TAF2J
  • TAFII20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
hub protein
0.9
histone modification site profile
0.85
virus perturbation
0.85
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.42   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.42   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Disease
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (132)
1 – 10 of 132
TAF11
Tbio
Novelty: 0.10299251
p_int: 0.999999996
p_ni: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF3
Tbio
Family: Epigenetic
Novelty: 0.05517331
p_int: 0.999999996
p_ni: 4e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
TAF1
Tchem
Family: Kinase
Novelty: 0.00555929
p_int: 0.999999994
p_ni: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
TAF13
Tbio
Novelty: 0.08566117
p_int: 0.999999991
p_ni: 3e-9
p_wrong: 5e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
TAF4B
Tbio
Novelty: 0.70515005
p_int: 0.999999988
p_ni: 1e-8
p_wrong: 2e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
ATXN7
Tbio
Novelty: 0.00323014
p_int: 0.99999998
p_ni: 1.8e-8
p_wrong: 2e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
TAF9B
Tbio
Novelty: 0.0285313
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
SUPT7L
Tdark
Novelty: 0.20661559
p_int: 0.999999966
p_ni: 3.3e-8
Score: 0.945
Data Source: BioPlex,STRINGDB
KAT2B
Tchem
Family: Epigenetic
Novelty: 0.00172126
p_int: 0.999999936
p_ni: 6.4e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
SUPT3H
Tbio
Novelty: 0.13202683
p_int: 0.999999896
p_ni: 1.04e-7
Score: 0.99
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.42

PubMed score by year
PubTator Score  15.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer