PKN2
Serine/threonine-protein kinase N2
Protein Classes
Protein Summary
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migr ...more
- ENST00000370513
- ENSP00000359544
- ENSG00000065243
- ENST00000370521
- ENSP00000359552
- PRK2
- PRKCL2
- PAK2
- PRK2
- STK7
- Pak-2
- PRKCL2
- PRO2042
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
interacting protein | 1 | ||
protein domain | 0.99 | ||
molecular function | 0.98 | ||
transcription factor binding site profile | 0.9 | ||
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.19 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.19 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (6)
1 – 6 of 6
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 2 | 4 | 93.7 | |||||
hematocrit | 1 | 1 | 1 | 68.2 | |||||
body height | 1 | 1 | 1 | 60.1 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 50.8 | |||||
hemoglobin measurement | 1 | 1 | 1 | 43.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 93.7 | |||||
hematocrit | 1 | 68.2 | |||||
body height | 1 | 60.1 | |||||
mean corpuscular hemoglobin concentration | 1 | 50.8 | |||||
hemoglobin measurement | 1 | 43.5 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protein kinase N2 | VGNC:1457 | 456998 | |||||
Macaque | protein kinase N2 | 693505 | ||||||
Mouse | MGI:109211 | 109333 | ||||||
Rat | RGD:620146 | 207122 | ||||||
Dog | protein kinase N2 | VGNC:44612 | 490174 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protein kinase N2 | |||||
Macaque | protein kinase N2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | protein kinase N2 | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (13)
Reactome (4)
KEGG (3)
PathwayCommons (5)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases activate PKNs | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Rho GTPases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
RHO GTPase Effectors | ||||
RHO GTPases activate PKNs | ||||
Signal Transduction | ||||
Signaling by Rho GTPases | ||||
Gene Ontology Terms (39)
Functions (10)
Components (14)
Processes (15)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | AgBase | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (77)
1 – 10 of 77
CETN1
Novelty: 0.01208917
p_int: 0.999994588
p_ni: 0.000005412
Score: 0.239
Data Source: BioPlex,STRINGDB
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.999641459
p_ni: 0.000358541
Data Source: BioPlex
FRMPD2
Novelty: 0.40302485
p_int: 0.998969254
p_ni: 0.001030746
Score: 0.54
Data Source: BioPlex,STRINGDB
RHOA
Family: Enzyme
Novelty: 0.00022204
p_int: 0.994655245
p_ni: 0.005344755
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
GOPC
Novelty: 0.01110168
p_int: 0.98159675
p_ni: 0.01840325
Score: 0.155
Data Source: BioPlex,STRINGDB
ZNF785
Family: TF
Novelty: 0.42629766
p_int: 0.964616076
p_ni: 0.035383924
Score: 0.152
Data Source: BioPlex,STRINGDB
DFFB
Novelty: 0.00475349
p_int: 0.947880762
p_ni: 0.052119237
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
TGM2
Family: Enzyme
Novelty: 0.0005293
p_int: 0.941885559
p_ni: 0.058114441
Data Source: BioPlex
TGFBR2
Family: Kinase
Novelty: 0.00085381
p_int: 0.876732036
p_ni: 0.123267964
Score: 0.191
Data Source: BioPlex,STRINGDB
DEF8
Novelty: 0.21146806
p_int: 0.862881016
p_ni: 0.137118984
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 116.19
PubMed score by year
PubTator Score 44.86
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
Find similar targets by:
UniProt Keyword
GWAS Trait