PKN2
Serine/threonine-protein kinase N2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug perturbation | 1 | ||
interacting protein | 1 | ||
protein domain | 0.99 | ||
molecular function | 0.98 | ||
transcription factor binding site profile | 0.9 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases activate PKNs | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Rho GTPases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
RHO GTPase Effectors | ||||
RHO GTPases activate PKNs | ||||
Signal Transduction | ||||
Signaling by Rho GTPases | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | AgBase | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 3 | 3 | 2 | 2.8 | 96 | ||||
body height | 3 | 3 | 3 | 92.3 | |||||
heel bone mineral density | 3 | 2 | 4 | 87.5 | |||||
aspartate aminotransferase measurement | 2 | 2 | 1 | 9.3 | 85.1 | ||||
BMI-adjusted waist circumference | 2 | 4 | 5 | 79.9 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 2.8 | 96 | ||||
body height | 3 | 92.3 | |||||
heel bone mineral density | 4 | 87.5 | |||||
aspartate aminotransferase measurement | 1 | 9.3 | 85.1 | ||||
BMI-adjusted waist circumference | 5 | 79.9 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | protein kinase N2 | VGNC:1457 | 456998 | |||||
Macaque | protein kinase N2 | 693505 | ||||||
Mouse | MGI:109211 | 109333 | ||||||
Rat | RGD:620146 | 207122 | ||||||
Dog | protein kinase N2 | VGNC:44612 | 490174 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | protein kinase N2 | |||||
Macaque | protein kinase N2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | protein kinase N2 | |||||
PMID | Year | Title |
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