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Tchem
PKN2
Serine/threonine-protein kinase N2

Protein Classes
Protein Summary
Description
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370513
  • ENSP00000359544
  • ENSG00000065243
  • ENST00000370521
  • ENSP00000359552

Symbol
  • PRK2
  • PRKCL2
  • PAK2
  • PRK2
  • STK7
  • Pak-2
  • PRKCL2
  • PRO2042
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
protein domain
0.99
molecular function
0.98
transcription factor binding site profile
0.9


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.19   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.19   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
midostaurin
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
4
93.7
hematocrit
1
1
1
68.2
body height
1
1
1
60.1
mean corpuscular hemoglobin concentration
1
1
1
50.8
hemoglobin measurement
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
93.7
hematocrit
1
68.2
body height
1
60.1
mean corpuscular hemoglobin concentration
1
50.8
hemoglobin measurement
1
43.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase N2
VGNC:1457
456998
Macaque
protein kinase N2
693505
Mouse
MGI:109211
109333
Rat
RGD:620146
207122
Dog
protein kinase N2
VGNC:44612
490174
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase N2
Macaque
protein kinase N2
Mouse
Rat
Dog
protein kinase N2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16513-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate PKNs
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases activate PKNs
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (77)
1 – 10 of 77
CETN1
Tbio
Novelty: 0.01208917
p_int: 0.999994588
p_ni: 0.000005412
Score: 0.239
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999641459
p_ni: 0.000358541
Data Source: BioPlex
FRMPD2
Tbio
Novelty: 0.40302485
p_int: 0.998969254
p_ni: 0.001030746
Score: 0.54
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
p_int: 0.994655245
p_ni: 0.005344755
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.98159675
p_ni: 0.01840325
Score: 0.155
Data Source: BioPlex,STRINGDB
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.964616076
p_ni: 0.035383924
Score: 0.152
Data Source: BioPlex,STRINGDB
DFFB
Tbio
Novelty: 0.00475349
p_int: 0.947880762
p_ni: 0.052119237
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
TGM2
Tchem
Family: Enzyme
Novelty: 0.0005293
p_int: 0.941885559
p_ni: 0.058114441
Data Source: BioPlex
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
p_int: 0.876732036
p_ni: 0.123267964
Score: 0.191
Data Source: BioPlex,STRINGDB
DEF8
Tdark
Novelty: 0.21146806
p_int: 0.862881016
p_ni: 0.137118984
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  116.19

PubMed score by year
PubTator Score  44.86

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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