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Tchem
PKN2
Serine/threonine-protein kinase N2

Protein Summary
Description
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370513
  • ENSP00000359544
  • ENSG00000065243
  • ENST00000370521
  • ENSP00000359552

Symbol
  • PRK2
  • PRKCL2
  • PAK2
  • PRK2
  • STK7
  • Pak-2
  • PRKCL2
  • PRO2042
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
protein domain
0.99
molecular function
0.98
transcription factor binding site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.78   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.78   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
midostaurin
chemical structure image
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate PKNs
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases activate PKNs
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (77)
1 – 10 of 77
CETN1
Tbio
Novelty: 0.01870324
p_int: 0.999994588
p_ni: 0.000005412
Score: 0.239
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.02297481
p_int: 0.999641459
p_ni: 0.000358541
Data Source: BioPlex
FRMPD2
Tbio
Novelty: 0.59102902
p_int: 0.998969254
p_ni: 0.001030746
Score: 0.54
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.0002729
p_int: 0.994655245
p_ni: 0.005344755
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
GOPC
Tbio
Novelty: 0.0164207
p_int: 0.98159675
p_ni: 0.01840325
Score: 0.155
Data Source: BioPlex,STRINGDB
ZNF785
Tdark
Family: TF
Novelty: 0.46153846
p_int: 0.964616076
p_ni: 0.035383924
Score: 0.152
Data Source: BioPlex,STRINGDB
DFFB
Tbio
Novelty: 0.00618651
p_int: 0.947880762
p_ni: 0.052119237
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
TGM2
Tchem
Family: Enzyme
Novelty: 0.00048324
p_int: 0.941885559
p_ni: 0.058114441
Data Source: BioPlex
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00128741
p_int: 0.876732036
p_ni: 0.123267964
Score: 0.191
Data Source: BioPlex,STRINGDB
DEF8
Tdark
Novelty: 0.4057481
p_int: 0.862881016
p_ni: 0.137118984
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  111.78

PubMed score by year
PubTator Score  44.86

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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