You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GRIK5
Glutamate receptor ionotropic, kainate 5

Protein Summary
Description
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD. This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262895
  • ENSP00000262895
  • ENSG00000105737
  • ENST00000301218
  • ENSP00000301218
  • ENST00000593562
  • ENSP00000470251

Symbol
  • GRIK2
  • KA2
  • EAA2
  • GRIK2
  • GluK5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
molecular function
0.93
biological process
0.74
protein domain
0.73
cell line
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.99   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.99   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
54.8
monocyte count
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
54.8
monocyte count
1
21
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95818
14809
Rat
RGD:2735
24407
Dog
glutamate ionotropic receptor kainate type subunit 5
VGNC:41490
484480
Horse
glutamate ionotropic receptor kainate type subunit 5
VGNC:51034
100069742
Opossum
glutamate ionotropic receptor kainate type subunit 5 [Source:HGNC Symbol;Acc:HGNC:4583]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
glutamate ionotropic receptor kainate type subunit 5
Horse
glutamate ionotropic receptor kainate type subunit 5
Opossum
glutamate ionotropic receptor kainate type subunit 5 [Source:HGNC Symbol;Acc:HGNC:4583]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16478-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Ionotropic activity of kainate receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of kainate receptors upon glutamate binding
Ionotropic activity of kainate receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (91)
1 – 10 of 91
GRIK2
Tclin
Family: IC
Novelty: 0.00293615
Score: 0.988
Data Source: Reactome,STRINGDB
GRIK3
Tclin
Family: IC
Novelty: 0.01816701
Score: 0.985
Data Source: Reactome,STRINGDB
GRIK1
Tclin
Family: IC
Novelty: 0.00283685
Score: 0.975
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.973
Data Source: STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.959
Data Source: STRINGDB
DLG1
Tbio
Novelty: 0.0050926
Score: 0.932
Data Source: STRINGDB
GRIK4
Tclin
Family: IC
Novelty: 0.0033299
Score: 0.909
Data Source: STRINGDB
NCALD
Tbio
Novelty: 0.03665351
Score: 0.903
Data Source: STRINGDB
GPR6
Tchem
Family: GPCR
Novelty: 0.05964344
Score: 0.829
Data Source: STRINGDB
KARS
Tchem
Family: Enzyme
Novelty: 0.00386511
Score: 0.79
Data Source: STRINGDB
Publication Statistics
PubMed Score  261.99

PubMed score by year
PubTator Score  59.57

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: