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Tclin
GABRA6
Gamma-aminobutyric acid receptor subunit alpha-6

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274545
  • ENSP00000274545
  • ENSG00000145863
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
protein domain
0.92
molecular function
0.9
ligand (chemical)
0.74
cell line
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.78   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.78   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
Approved Drugs (14)
1 – 10 of 14
halothane
chemical structure image
isoflurane
chemical structure image
desflurane
chemical structure image
sevoflurane
chemical structure image
methoxyflurane
chemical structure image
metharbital
chemical structure image
talbutal
chemical structure image
triclofos
chemical structure image
thiamylal
chemical structure image
halazepam
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
79.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
79.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor alpha6 subunit
VGNC:8619
471725
Macaque
gamma-aminobutyric acid type A receptor alpha6 subunit
697010
Mouse
MGI:95618
14399
Rat
RGD:61861
29708
Dog
gamma-aminobutyric acid type A receptor alpha6 subunit
VGNC:51895
489145
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor alpha6 subunit
Macaque
gamma-aminobutyric acid type A receptor alpha6 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor alpha6 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16445-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (187)
1 – 10 of 187
GABRB3
Tclin
Family: IC
Novelty: 0.00485997
p_int: 0.999966604
p_ni: 0.000033396
Score: 0.967
Data Source: BioPlex,STRINGDB
EHD2
Tbio
Novelty: 0.02724854
p_int: 0.999872732
p_ni: 0.000127268
Score: 0.209
Data Source: BioPlex,STRINGDB
ZMYND19
Tdark
Novelty: 0.3590069
p_int: 0.99699501
p_ni: 0.00300499
Data Source: BioPlex
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
p_int: 0.993465465
p_ni: 0.006534535
Score: 0.195
Data Source: BioPlex,STRINGDB
PDZD8
Tbio
Novelty: 0.09015543
p_int: 0.981308268
p_ni: 0.018691732
Data Source: BioPlex
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.978191925
p_ni: 0.021808075
Data Source: BioPlex
HMGCR
Tclin
Family: Enzyme
Novelty: 0.00046789
p_int: 0.97357521
p_ni: 0.026424789
Score: 0.187
Data Source: BioPlex,STRINGDB
BSCL2
Tbio
Novelty: 0.00483959
p_int: 0.961369116
p_ni: 0.038630884
Score: 0.183
Data Source: BioPlex,STRINGDB
ST7L
Tbio
Novelty: 0.03661324
p_int: 0.937414532
p_ni: 0.062585414
p_wrong: 5.4e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
PCNX3
Tdark
Novelty: 0.76597717
p_int: 0.845316333
p_ni: 0.154683389
p_wrong: 2.78e-7
Score: 0.202
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  30.78

PubMed score by year
PubTator Score  21.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer