Tbio EXT1 Exostosin-1

Protein Summary

Description

Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16394
• B2R7V2
• Q9BVI9

Gene Name

• EXT1

Ensembl ID

• ENST00000378204
• ENSP00000367446
• ENSG00000182197

Symbol

• EXT
• LGS
• TTV
• LGCR
• TRPS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.95
kinase perturbation	0.93
transcription factor binding site profile	0.91
transcription factor perturbation	0.88
trait	0.86

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Exostosin-1

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Exostosin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 403.64   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 403.64   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0