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Tbio
PRR4
Proline-rich protein 4

Protein Summary
Description
This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228811
  • ENSP00000228811
  • ENSG00000111215
  • ENST00000544994
  • ENSP00000438046
  • ENST00000574424
  • ENSP00000459468
  • ENSG00000263247
  • ENST00000576999
  • ENSP00000461695
  • ENST00000614435
  • ENSP00000477689
  • ENSG00000282269
  • ENST00000632373
  • ENSP00000487830

Symbol
  • LPRP
  • PROL4
  • LPRP
  • PROL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
interacting protein
0.61
tissue
0.57
cell line
0.53
small molecule perturbation
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of bitter taste
2
4
4
91.1
sensory perception of bitter taste
2
4
4
91.1
tea consumption measurement
2
2
2
60.4
tea consumption measurement
2
2
2
60.4
coffee consumption measurement
1
1
1
31.4
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of bitter taste
4
91.1
sensory perception of bitter taste
4
91.1
tea consumption measurement
2
60.4
tea consumption measurement
2
60.4
coffee consumption measurement
1
31.4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16378-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (22)
1 – 10 of 22
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999995368
p_ni:  1.92e-7
p_wrong:  0.000004439
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999962098
p_ni:  0.000017454
p_wrong:  0.000020448
Data Source:  BioPlex
HBM
Tdark
Novelty:  0.02658671
p_int:  0.999174233
p_ni:  0.00003703
p_wrong:  0.000788737
Score:  0.189
Data Source:  BioPlex,STRINGDB
KCNIP4
Tbio
Family:  IC
Novelty:  0.00973829
p_int:  0.904030186
p_ni:  0.002089158
p_wrong:  0.093880657
Score:  0.241
Data Source:  BioPlex,STRINGDB
SLC25A10
Tbio
Family:  Transporter
Novelty:  0.03534249
p_int:  0.866704352
p_ni:  0.002982598
p_wrong:  0.13031305
Data Source:  BioPlex
LACRT
Tbio
Novelty:  0.03333799
Score:  0.691
Data Source:  STRINGDB
LCN1
Tbio
Novelty:  0.00510137
Score:  0.669
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.627
Data Source:  STRINGDB
PIP
Tbio
Novelty:  0.00208509
Score:  0.56
Data Source:  STRINGDB
SCGB2A1
Tbio
Novelty:  0.01902973
Score:  0.556
Data Source:  STRINGDB
Publication Statistics
PubMed Score  101.85

PubMed score by year
PubTator Score  25.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer