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Tbio
INA
Alpha-internexin

Protein Summary
Description
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369849
  • ENSP00000358865
  • ENSG00000148798

Symbol
  • NEF5
  • NEF5
  • NF-66
  • TXBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
PubMedID
0.82
gene perturbation
0.71
cellular component
0.7
tissue sample
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.9   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 444   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.9   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
2
3
2
7.2
72.1
body height
1
1
1
69.2
1
2
2
68.4
pulse pressure measurement
1
1
1
67.9
cortical surface area measurement
1
1
0
773.2
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
2
7.2
72.1
body height
1
69.2
2
68.4
pulse pressure measurement
1
67.9
cortical surface area measurement
0
773.2
67.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
internexin neuronal intermediate filament protein alpha
VGNC:5479
450709
Macaque
internexin neuronal intermediate filament protein alpha
714455
Mouse
MGI:96568
226180
Rat
RGD:2911
24503
Dog
internexin neuronal intermediate filament protein alpha
VGNC:42014
486869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
internexin neuronal intermediate filament protein alpha
Macaque
internexin neuronal intermediate filament protein alpha
Mouse
Rat
Dog
internexin neuronal intermediate filament protein alpha
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16352-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (53)
1 – 10 of 53
NEFM
Tbio
Novelty:  0.00239134
p_int:  0.999999748
p_ni:  2.52e-7
Score:  0.83
Data Source:  BioPlex,STRINGDB
VIM
Tbio
Novelty:  0.00030317
p_int:  0.999996709
p_ni:  0.000003291
Score:  0.817
Data Source:  BioPlex,STRINGDB
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999993008
p_ni:  0.000006992
Score:  0.311
Data Source:  BioPlex,STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999968325
p_ni:  0.000031675
Data Source:  BioPlex
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.999964273
p_ni:  0.000035727
Score:  0.215
Data Source:  BioPlex,STRINGDB
NEFH
Tbio
Novelty:  0.0013027
p_int:  0.999937342
p_ni:  0.000062658
Score:  0.4
Data Source:  BioPlex,STRINGDB
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.999729913
p_ni:  0.000270079
p_wrong:  8e-9
Data Source:  BioPlex
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.999717474
p_ni:  0.000282526
Score:  0.692
Data Source:  BioPlex,STRINGDB
MIPEP
Tbio
Family:  Enzyme
Novelty:  0.01507033
p_int:  0.998265147
p_ni:  0.001734853
Data Source:  BioPlex
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.994619905
p_ni:  0.005380092
p_wrong:  3e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  130.90

PubMed score by year
PubTator Score  263.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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