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Tchem
SLC15A2
Solute carrier family 15 member 2

Protein Summary
Description
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7756356). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity). The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295605
  • ENSP00000295605
  • ENSG00000163406
  • ENST00000489711
  • ENSP00000417085

Symbol
  • PEPT2
  • PEPT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.99
PubMedID
0.91
molecular function
0.81
gene perturbation
0.76
protein domain
0.73


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.57   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.57   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
2
2
0
1
89.3
2
2
0
1
89.3
hemoglobin measurement
2
2
2
81.5
hematocrit
2
2
2
80.9
glomerular filtration rate
5
5
5
7.6
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
0
1
89.3
0
1
89.3
hemoglobin measurement
2
81.5
hematocrit
2
80.9
glomerular filtration rate
5
7.6
80.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 15 member 2
VGNC:7997
460627
Macaque
solute carrier family 15 member 2
574375
Mouse
MGI:1890457
57738
Rat
RGD:61972
60577
Dog
solute carrier family 15 member 2
VGNC:46233
488006
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 15 member 2
Macaque
solute carrier family 15 member 2
Mouse
Rat
Dog
solute carrier family 15 member 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16348-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Proton/oligopeptide cotransporters (R-HSA-427975)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Proton/oligopeptide cotransporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Proton/oligopeptide cotransporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (72)
1 – 10 of 72
SLC22A8
Tclin
Family: Transporter
Novelty: 0.00291642
Score: 0.733
Data Source: STRINGDB
SLC22A6
Tclin
Family: Transporter
Novelty: 0.00389149
Score: 0.71
Data Source: STRINGDB
POLR1A
Tchem
Family: Enzyme
Novelty: 0.0485107
Score: 0.675
Data Source: STRINGDB
SLC22A5
Tbio
Family: Transporter
Novelty: 0.00290828
Score: 0.667
Data Source: STRINGDB
SLC22A4
Tbio
Family: Transporter
Novelty: 0.00432387
Score: 0.656
Data Source: STRINGDB
ACE
Tclin
Family: Enzyme
Novelty: 0.00001993
Score: 0.65
Data Source: STRINGDB
ACE2
Tchem
Family: Enzyme
Novelty: 0.00028408
Score: 0.65
Data Source: STRINGDB
SPON1
Tbio
Novelty: 0.01071398
Score: 0.624
Data Source: STRINGDB
SLC22A13
Tbio
Family: Transporter
Novelty: 0.04702774
Score: 0.605
Data Source: STRINGDB
SLCO2B1
Tchem
Family: Transporter
Novelty: 0.00517974
Score: 0.589
Data Source: STRINGDB
Publication Statistics
PubMed Score  182.57

PubMed score by year
PubTator Score  85.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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