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Tclin
KCNA10
Potassium voltage-gated channel subfamily A member 10

Protein Summary
Description
Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domain ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369771
  • ENSP00000358786
  • ENSG00000143105

Symbol
  • Kcn1
  • Kv1.8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.9
cell type or tissue
0.78
cell line
0.56
chemical
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.25   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.25   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (106)
REEP1
Tbio
Novelty:  0.02280713
p_int:  0.99998514
p_ni:  0.000014857
p_wrong:  3e-9
Score:  0.566
Data Source:  BioPlex,STRINGDB
EXTL2
Tbio
Family:  Enzyme
Novelty:  0.05051027
p_int:  0.992766471
p_ni:  0.007196118
p_wrong:  0.00003741
Data Source:  BioPlex
MINDY1
Tbio
Novelty:  0.31540765
p_int:  0.992464842
p_ni:  0.007263551
p_wrong:  0.000271607
Score:  0.167
Data Source:  BioPlex,STRINGDB
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.986527231
p_ni:  0.013472561
p_wrong:  2.07e-7
Data Source:  BioPlex
NAT14
Tbio
Family:  Enzyme
Novelty:  0.08842982
p_int:  0.975719253
p_ni:  0.024280747
Score:  0.383
Data Source:  BioPlex,STRINGDB
CHSY1
Tbio
Family:  Enzyme
Novelty:  0.03515909
p_int:  0.969716957
p_ni:  0.030283043
Score:  0.199
Data Source:  BioPlex,STRINGDB
GOLM1
Tbio
Novelty:  0.00752112
p_int:  0.968138612
p_ni:  0.031861388
Data Source:  BioPlex
C1orf43
Tbio
Novelty:  0.13587458
p_int:  0.94894041
p_ni:  0.051059471
p_wrong:  1.19e-7
Data Source:  BioPlex
SLC12A9
Tdark
Family:  Transporter
Novelty:  0.12936696
p_int:  0.945990289
p_ni:  0.054009711
Data Source:  BioPlex
REEP4
Tbio
Novelty:  0.37950931
p_int:  0.870303188
p_ni:  0.129685363
p_wrong:  0.00001145
Score:  0.395
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
1
1
34.9
carotid artery intima media thickness
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
34.9
carotid artery intima media thickness
1
5.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A member 10
VGNC:8055
469414
Macaque
potassium voltage-gated channel subfamily A member 10
702008
Mouse
MGI:3037820
242151
Rat
RGD:1304667
295360
Dog
potassium voltage-gated channel subfamily A member 10
VGNC:42228
490111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A member 10
Macaque
potassium voltage-gated channel subfamily A member 10
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A member 10
Publication Statistics
PubMed Score 19.25
PubMed score by year
PubTator Score 8.75
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title