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Tchem
CNGA3
Cyclic nucleotide-gated cation channel alpha-3

Protein Summary
Description
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272602
  • ENSP00000272602
  • ENSG00000144191
  • ENST00000393504
  • ENSP00000377140
  • ENST00000409937
  • ENSP00000386761
  • ENST00000436404
  • ENSP00000410070

Symbol
  • CNCG3
  • CNG3
  • ACHM2
  • CCNC1
  • CCNCa
  • CNCG3
  • CCNCalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
cellular component
0.85
protein domain
0.73
transcription factor
0.57
biological process
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.3   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.3   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (102)
1 – 10 of 102
ACBD5
Tbio
Novelty: 0.10433432
p_int: 0.999999987
p_ni: 1e-9
p_wrong: 1.2e-8
Score: 0.272
Data Source: BioPlex,STRINGDB
VPS52
Tbio
Novelty: 0.01439614
p_int: 0.999876054
p_ni: 0.000123946
Data Source: BioPlex
SEMG2
Tbio
Novelty: 0.06325799
p_int: 0.999649417
p_ni: 0.000350583
Data Source: BioPlex
C1orf43
Tbio
Novelty: 0.13587458
p_int: 0.99903629
p_ni: 0.000963708
p_wrong: 2e-9
Data Source: BioPlex
ABCB9
Tbio
Family: Transporter
Novelty: 0.02217672
p_int: 0.998740651
p_ni: 0.001259318
p_wrong: 3.1e-8
Data Source: BioPlex
SEMG1
Tbio
Novelty: 0.0161449
p_int: 0.998278071
p_ni: 0.001721928
Data Source: BioPlex
PDZD8
Tbio
Novelty: 0.09015543
p_int: 0.997607927
p_ni: 0.002392073
Data Source: BioPlex
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
p_int: 0.997284761
p_ni: 0.002715239
p_wrong: 1e-9
Data Source: BioPlex
ADCY3
Tbio
Family: Enzyme
Novelty: 0.00260265
p_int: 0.996491387
p_ni: 0.003484416
p_wrong: 0.000024198
Score: 0.376
Data Source: BioPlex,STRINGDB
RAB6B
Tbio
Family: Enzyme
Novelty: 0.0865097
p_int: 0.994998749
p_ni: 0.005001211
p_wrong: 3.9e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  139.30

PubMed score by year
PubTator Score  75.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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