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Tchem
CNGA2
Cyclic nucleotide-gated olfactory channel

Protein Summary
Description
Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329903
  • ENSP00000328478
  • ENSG00000183862

Symbol
  • CNCA
  • CNCA1
  • CNCG2
  • CNCA
  • CNG2
  • CNCA1
  • OCNC1
  • OCNCa
  • OCNCALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.73
ligand (protein)
0.68
gene perturbation
0.62
cell type or tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.23   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.23   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (78)
CNGB1
Tbio
Family:  IC
Novelty:  0.01034916
Score:  0.948
Data Source:  Reactome,STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.93
Data Source:  STRINGDB
ARF4
Tbio
Family:  Enzyme
Novelty:  0.01166211
Score:  0.922
Data Source:  Reactome,STRINGDB
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
Score:  0.919
Data Source:  STRINGDB
PKD1
Tbio
Novelty:  0.00288432
Score:  0.909
Data Source:  STRINGDB
CNGA4
Tbio
Family:  IC
Novelty:  0.05605027
Score:  0.908
Data Source:  Reactome,STRINGDB
EXOC5
Tbio
Novelty:  0.02200205
Score:  0.906
Data Source:  STRINGDB
ASAP1
Tbio
Novelty:  0.00913771
Score:  0.905
Data Source:  Reactome,STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
Score:  0.903
Data Source:  Reactome,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
Score:  0.901
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
CALM1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
CALM3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
CALM2
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
Pathways (31)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
VxPx cargo-targeting to cilium
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
VxPx cargo-targeting to cilium
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel alpha 2
VGNC:1399
107966393
Mouse
MGI:108040
12789
Rat
Dog
cyclic nucleotide gated channel alpha 2
VGNC:39396
612414
Horse
cyclic nucleotide gated channel alpha 2
VGNC:16664
100069276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel alpha 2
Mouse
Rat
Dog
cyclic nucleotide gated channel alpha 2
Horse
cyclic nucleotide gated channel alpha 2
Publication Statistics
PubMed Score 93.23
PubMed score by year
PubTator Score 29.93
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title