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Tbio
E2F4
Transcription factor E2F4

Protein Summary
Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dim ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379378
  • ENSP00000368686
  • ENSG00000205250

Symbol
  • E2F-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
kinase perturbation
0.84
molecular function
0.84
biological process
0.81
transcription factor binding site profile
0.75


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Target Illumination GWAS Analytics (TIGA)
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.55   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.55   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
2
2
59.9
mean reticulocyte volume
1
2
2
42.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
59.9
mean reticulocyte volume
2
42.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 4
VGNC:8979
454158
Macaque
E2F transcription factor 4
696864
Mouse
MGI:103012
104394
Rat
RGD:2322129
100360427
Dog
E2F transcription factor 4
VGNC:40166
611243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 4
Macaque
E2F transcription factor 4
Mouse
Rat
Dog
E2F transcription factor 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16254-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin D associated events in G1
Reactome
Cyclin E associated events during G1/S transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Cyclin E associated events during G1/S transition
Gene Ontology Terms (27)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (178)
1 – 10 of 178
TFDP2
Tbio
Family: TF
Novelty: 0.14331363
p_int: 0.999999963
p_ni: 3.3e-8
p_wrong: 5e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
POMC
Tbio
Novelty: 0.00002436
p_int: 0.999997002
p_ni: 0.000002953
p_wrong: 4.5e-8
Score: 0.451
Data Source: BioPlex,STRINGDB
CCDC183
Tdark
Novelty: 1.55719016
p_int: 0.999995853
p_ni: 0.000004138
p_wrong: 1e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
TFDP3
Tbio
Family: TF
Novelty: 0.00223003
p_int: 0.999984867
p_ni: 4.11e-7
p_wrong: 0.000014722
Score: 0.949
Data Source: BioPlex,STRINGDB
GMNN
Tbio
Novelty: 0.00436572
p_int: 0.999800798
p_ni: 0.000014806
p_wrong: 0.000184396
Score: 0.444
Data Source: BioPlex,STRINGDB
CDKN2AIP
Tbio
Novelty: 0.15331029
p_int: 0.999738299
p_ni: 0.00001476
p_wrong: 0.000246941
Data Source: BioPlex
RBL1
Tbio
Novelty: 0.00228265
Score: 0.999
Data Source: Reactome,STRINGDB
TFDP1
Tbio
Family: TF
Novelty: 0.02026858
Score: 0.998
Data Source: Reactome,STRINGDB
RBL2
Tbio
Novelty: 0.00121893
Score: 0.997
Data Source: Reactome,STRINGDB
RB1
Tchem
Novelty: 0.00063798
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  281.55

PubMed score by year
PubTator Score  162.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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