Tchem NFE2L2 Nuclear factor erythroid 2-related factor 2

Protein Summary

Description

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• Q16236
• B2RBU2
• B4E338
• E9PGJ7
• Q53RW6
• Q59HH2
• Q96F71
• NF-E2-related factor 2

Gene Name

• NFE2L2

Ensembl ID

• ENST00000397062
• ENSP00000380252
• ENSG00000116044
• ENST00000397063
• ENSP00000380253
• ENST00000446151
• ENSP00000411575
• ENST00000464747
• ENSP00000467401

Symbol

• NRF2
• NRF2
• HEBP1
• IMDDHH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
transcription factor binding site profile	0.99
phenotype	0.98
biological process	0.97
kinase perturbation	0.96

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Factor Erythroid 2-related Factor 2

Protein / Nucleic Acid Binding / Nuclear Factor Erythroid 2-related Factor 2

Protein / Hydrolase / Nuclear Factor Erythroid 2-related Factor 2

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Nuclear Factor Erythroid 2-related Factor 2

DTO Classes

Protein / Enzyme / Hydrolase / Nuclear Factor Erythroid 2-related Factor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3530.21   (req: < 5)

Gene RIFs: 1665   (req: <= 3)

Antibodies: 761   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3530.21   (req: >= 5)

Gene RIFs: 1665   (req: > 3)

Antibodies: 761   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 83

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0