Tbio UAP1 UDP-N-acetylhexosamine pyrophosphorylase

Protein Summary

Description

Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.

Uniprot Accession IDs

• Q16222
• B2R6R8
• Q5VTA9
• Q5VTB0
• Q5VTB1
• Q96GM2

Gene Name

• UAP1

Ensembl ID

• ENST00000271469
• ENSP00000271469
• ENSG00000117143
• ENST00000367924
• ENSP00000356901
• ENST00000367925
• ENSP00000356902
• ENST00000367926
• ENSP00000356903

Symbol

• SPAG2
• AGX
• AGX1
• AGX2
• SPAG2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
histone modification site profile	0.83
disease perturbation	0.74
transcription factor perturbation	0.74
tissue	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.74   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.74   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0