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Tbio
UAP1
UDP-N-acetylhexosamine pyrophosphorylase

Protein Summary
Description
Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271469
  • ENSP00000271469
  • ENSG00000117143
  • ENST00000367924
  • ENSP00000356901
  • ENST00000367925
  • ENSP00000356902
  • ENST00000367926
  • ENSP00000356903

Symbol
  • SPAG2
  • AGX
  • AGX1
  • AGX2
  • SPAG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.83
disease perturbation
0.74
transcription factor perturbation
0.74
tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.986460478
p_ni:  0.013539522
Score:  0.189
Data Source:  BioPlex,STRINGDB
NFYA
Tbio
Family:  TF
Novelty:  0.00507094
p_int:  0.796210133
p_ni:  0.203789867
Score:  0.309
Data Source:  BioPlex,STRINGDB
PGM3
Tbio
Family:  Enzyme
Novelty:  0.00515842
Score:  0.991
Data Source:  STRINGDB
GNE
Tbio
Family:  Enzyme
Novelty:  0.00285751
Score:  0.97
Data Source:  STRINGDB
GALE
Tchem
Family:  Enzyme
Novelty:  0.00256798
Score:  0.959
Data Source:  STRINGDB
GNPNAT1
Tbio
Family:  Enzyme
Novelty:  0.01739665
Score:  0.847
Data Source:  STRINGDB
SCLY
Tbio
Family:  Enzyme
Novelty:  0.05154464
Score:  0.825
Data Source:  STRINGDB
UAP1L1
Tdark
Family:  Enzyme
Novelty:  0.36065169
Score:  0.806
Data Source:  STRINGDB
GFPT1
Tchem
Family:  Enzyme
Novelty:  0.00358283
Score:  0.75
Data Source:  STRINGDB
SLC37A2
Tbio
Family:  Transporter
Novelty:  0.08172762
Score:  0.74
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of UDP-N-acetyl-glucosamine
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of UDP-N-acetyl-glucosamine
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
28.1
adolescent idiopathic scoliosis
1
1
0
1.5
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
28.1
adolescent idiopathic scoliosis
0
1.5
0.6
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-N-acetylglucosamine pyrophosphorylase 1
VGNC:10907
457466
Macaque
UDP-N-acetylglucosamine pyrophosphorylase 1
720116
Mouse
MGI:1334459
107652
Rat
RGD:1561967
498272
Dog
UDP-N-acetylglucosamine pyrophosphorylase 1
VGNC:48035
488664
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-N-acetylglucosamine pyrophosphorylase 1
Macaque
UDP-N-acetylglucosamine pyrophosphorylase 1
Mouse
Rat
Dog
UDP-N-acetylglucosamine pyrophosphorylase 1
Publication Statistics
PubMed Score 53.06
PubMed score by year
PubTator Score 35.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title