Tbio ENOX2 Ecto-NOX disulfide-thiol exchanger 2

Protein Summary

Description

May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q16206
• A8K197
• A8K1C2
• Q5VTJ1
• Q5VTJ2
• Q8WUX0
• Q9NTP6
• Q9UH82

Gene Name

• ENOX2

Ensembl ID

• ENST00000338144
• ENSP00000337146
• ENSG00000165675
• ENST00000370927
• ENSP00000359965
• ENST00000370935
• ENSP00000359973
• ENST00000394363
• ENSP00000377890

Symbol

• COVA1
• APK1
• tNOX
• COVA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
kinase perturbation	0.76
transcription factor perturbation	0.68
virus perturbation	0.68
histone modification site profile	0.62

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Ecto-nox Disulfide-thiol Exchanger 2

Protein / Nucleic Acid Binding / Nuclease / Ecto-nox Disulfide-thiol Exchanger 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Ecto-nox Disulfide-thiol Exchanger 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.27   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.27   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0