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Tbio
ADRM1
Proteasomal ubiquitin receptor ADRM1

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiqui ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253003
  • ENSP00000253003
  • ENSG00000130706
  • ENST00000491935
  • ENSP00000478877

Symbol
  • GP110
  • ARM1
  • ARM-1
  • GP110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
ligand (protein) perturbation
0.96
transcription factor binding site profile
0.87
phenotype
0.85
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.45   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.45   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (197)
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.999999778
p_ni:  2.22e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CCDC92
Tbio
Novelty:  0.32125749
p_int:  0.999972323
p_ni:  0.000027677
Score:  0.838
Data Source:  BioPlex,STRINGDB
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.999884102
p_ni:  0.000115898
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD10
Tbio
Family:  Enzyme
Novelty:  0.01331382
p_int:  0.999724386
p_ni:  0.000275614
Score:  0.995
Data Source:  BioPlex,STRINGDB
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.999722298
p_ni:  0.000277702
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.999703155
p_ni:  0.000296845
Score:  0.999
Data Source:  BioPlex,STRINGDB
PIPSL
Tdark
p_int:  0.999361849
p_ni:  0.000635457
p_wrong:  0.000002694
Data Source:  BioPlex
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
p_int:  0.999024756
p_ni:  0.000975244
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
p_int:  0.998691864
p_ni:  0.001308136
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD14
Tchem
Family:  Enzyme
Novelty:  0.01019285
p_int:  0.998458053
p_ni:  0.001541947
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
UCH proteinases
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
0
1.2
92.6
1
1
0
1.1
77.9
reticulocyte measurement
2
1
2
71.2
glomerular filtration rate
2
2
2
69.1
reticulocyte count
2
1
2
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
92.6
0
1.1
77.9
reticulocyte measurement
2
71.2
glomerular filtration rate
2
69.1
reticulocyte count
2
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion regulating molecule 1
VGNC:6034
458386
Macaque
adhesion regulating molecule 1
699928
Mouse
MGI:1929289
56436
Rat
RGD:69248
65138
Dog
adhesion regulating molecule 1
VGNC:37678
100855986
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion regulating molecule 1
Macaque
adhesion regulating molecule 1
Mouse
Rat
Dog
adhesion regulating molecule 1
Publication Statistics
PubMed Score 79.45
PubMed score by year
PubTator Score 195.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title