Tbio SEPT7 Septin-7

Protein Summary

Description

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q16181
• Q52M76
• Q6NX50

Gene Name

• SEPT7

Ensembl ID

• ENST00000399034
• ENSP00000381992
• ENSG00000122545

Symbol

• CDC10
• CDC3
• CDC10
• SEPT7A
• NBLA02942

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
transcription factor perturbation	0.96
cellular component	0.84
cell type or tissue	0.82
molecular function	0.81

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-7

Protein / Cytoskeletal Protein / Septin-7

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.37   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.37   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0