Pharos: Illuminating the Druggable Genome

Tbio

Protein Classes

Protein Summary

Description

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

Gene Name

SNCB

Ensembl ID

ENST00000310112
ENSP00000308057
ENSG00000074317
ENST00000393693
ENSP00000377296
ENST00000506696
ENSP00000422223
ENST00000510387
ENSP00000424073

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.74

cellular component	0.69

kinase	0.67

cell type or tissue	0.65

histone modification site profile	0.6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.55 (req: < 5)

View Publications

Gene RIFs: 38 (req: <= 3)

View Gene RIFs

Antibodies: 346 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.55 (req: >= 5)

Gene RIFs: 38 (req: > 3)

Antibodies: 346 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (4)

Reactome (3)

PathwayCommons (1)

Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Reactome	MTF1 activates gene expression	3 targets	R-HSA-5660489

Reactome	Response to metal ions	14 targets	R-HSA-5660526

Name	Explore in Pharos	Explore in Source
Cellular responses to external stimuli	487 targets	R-HSA-8953897

MTF1 activates gene expression	3 targets	R-HSA-5660489

Response to metal ions	14 targets	R-HSA-5660526

Gene Ontology Terms (13)

Functions (4)

Components (3)

Processes (6)

Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB

cuprous ion binding	Inferred from Mutant Phenotype (IMP)	CAFA

transition metal ion binding	Inferred from Mutant Phenotype (IMP)	CAFA

phospholipase inhibitor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (188)

1 – 10 of 188

See Interactions on String-DB

NUFIP1

Tbio

Novelty: 0.14861119

p_int: 0.997939094

p_ni: 0.000364018

p_wrong: 0.001696888

Data Source: BioPlex

DNAAF2

Tbio

Novelty: 0.04657397

p_int: 0.997939094

p_ni: 0.000364018

p_wrong: 0.001696888

Data Source: BioPlex

DGUOK

Tbio

Family: Kinase

Novelty: 0.00695477

p_int: 0.997924975

p_ni: 0.000333936

p_wrong: 0.001741089

Data Source: BioPlex

ARMC1

Tbio

Novelty: 0.02013423

p_int: 0.983720956

p_ni: 0.014839848

p_wrong: 0.001439196

Score: 0.19

Data Source: BioPlex,STRINGDB

MTF1

Tbio

Family: TF

Novelty: 0.01143388

Score: 0.9

Data Source: STRINGDB

RAB3A

Tbio

Family: Enzyme

Novelty: 0.00506015

Score: 0.727

Data Source: STRINGDB

UNC5A

Tbio

Novelty: 0.05365755

Score: 0.698

Data Source: STRINGDB

TMEM263

Tdark

Novelty: 1.55555556

Score: 0.687

Data Source: STRINGDB

TSACC

Tbio

Novelty: 5

Score: 0.684

Data Source: STRINGDB

SNAP25

Tclin

Novelty: 0.0020914

Score: 0.67

Data Source: STRINGDB

Publication Statistics

PubMed Score 110.55

PubMed score by year

PubTator Score 76.58

PubTator score by year

Amino Acid Sequence

Residue Counts

Sequence

MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAV

1-70

FSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA

70-134

MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA

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Complete proteome

Cytoplasm

Direct protein sequencing

Phosphoprotein

Reference proteome

Repeat