Protein Classes
Protein Summary
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- ENST00000310112
- ENSP00000308057
- ENSG00000074317
- ENST00000393693
- ENSP00000377296
- ENST00000506696
- ENSP00000422223
- ENST00000510387
- ENSP00000424073
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.74 | ||
cellular component | 0.69 | ||
kinase | 0.67 | ||
cell type or tissue | 0.65 | ||
histone modification site profile | 0.6 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.55 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 346 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.55 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 346 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (4)
Reactome (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | MTF1 activates gene expression | ||||
Reactome | Response to metal ions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular responses to external stimuli | ||||
MTF1 activates gene expression | ||||
Response to metal ions | ||||
Gene Ontology Terms (13)
Functions (4)
Components (3)
Processes (6)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (188)
1 – 10 of 188
NUFIP1
Novelty: 0.14861119
p_int: 0.997939094
p_ni: 0.000364018
p_wrong: 0.001696888
Data Source: BioPlex
DNAAF2
Novelty: 0.04657397
p_int: 0.997939094
p_ni: 0.000364018
p_wrong: 0.001696888
Data Source: BioPlex
DGUOK
Family: Kinase
Novelty: 0.00695477
p_int: 0.997924975
p_ni: 0.000333936
p_wrong: 0.001741089
Data Source: BioPlex
ARMC1
Novelty: 0.02013423
p_int: 0.983720956
p_ni: 0.014839848
p_wrong: 0.001439196
Score: 0.19
Data Source: BioPlex,STRINGDB
MTF1
Family: TF
Novelty: 0.01143388
Score: 0.9
Data Source: STRINGDB
RAB3A
Family: Enzyme
Novelty: 0.00506015
Score: 0.727
Data Source: STRINGDB
UNC5A
Novelty: 0.05365755
Score: 0.698
Data Source: STRINGDB
TMEM263
Novelty: 1.55555556
Score: 0.687
Data Source: STRINGDB
TSACC
Novelty: 5
Score: 0.684
Data Source: STRINGDB
SNAP25
Novelty: 0.0020914
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score 110.55
PubMed score by year
PubTator Score 76.58
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAV
1-70
FSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA
70-134
MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFSGAGNIAAATGLVKREEFPTDLKPEEVAQEAAEEPLIEPLMEPEGESYEDPPQEEYQEYEPEA
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