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Tclin
GRIK4
Glutamate receptor ionotropic, kainate 4

Protein Summary
Description
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000438375
  • ENSP00000404063
  • ENSG00000149403
  • ENST00000527524
  • ENSP00000435648
  • ENST00000638419
  • ENSP00000492086

Symbol
  • GRIK
  • KA1
  • EAA1
  • GRIK
  • GluK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
protein domain
0.73
disease
0.64
trait
0.61
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.87   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 279.87   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
topiramate
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
4
5
86.1
self reported educational attainment
1
1
1
66.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
86.1
self reported educational attainment
1
66.7
Pathways (11)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Ionotropic activity of kainate receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of kainate receptors upon glutamate binding
Ionotropic activity of kainate receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Protein-Protein Interactions (84)
1 – 10 of 84
GRIK2
Tclin
Family: IC
Novelty: 0.00293615
Score: 0.98
Data Source: Reactome,STRINGDB
GRIK3
Tclin
Family: IC
Novelty: 0.01816701
Score: 0.975
Data Source: Reactome,STRINGDB
GRIK1
Tclin
Family: IC
Novelty: 0.00283685
Score: 0.973
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.952
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.938
Data Source: Reactome,STRINGDB
DLG1
Tbio
Novelty: 0.0050926
Score: 0.925
Data Source: STRINGDB
GRIK5
Tclin
Family: IC
Novelty: 0.00346213
Score: 0.909
Data Source: STRINGDB
NCALD
Tbio
Novelty: 0.03665351
Score: 0.903
Data Source: STRINGDB
MARK4
Tchem
Family: Kinase
Novelty: 0.01908376
Score: 0.808
Data Source: STRINGDB
GRM4
Tchem
Family: GPCR
Novelty: 0.00380434
Score: 0.792
Data Source: STRINGDB
Publication Statistics
PubMed Score  279.87

PubMed score by year
PubTator Score  87.21

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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