You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GRIK4
Glutamate receptor ionotropic, kainate 4

Protein Summary
Description
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000438375
  • ENSP00000404063
  • ENSG00000149403
  • ENST00000527524
  • ENSP00000435648
  • ENST00000638419
  • ENSP00000492086

Symbol
  • GRIK
  • KA1
  • EAA1
  • GRIK
  • GluK4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
protein domain
0.73
disease
0.64
trait
0.61
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.92   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.92   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
GRIK2
Tclin
Family:  IC
Novelty:  0.00293615
Score:  0.98
Data Source:  Reactome,STRINGDB
GRIK3
Tclin
Family:  IC
Novelty:  0.01816701
Score:  0.975
Data Source:  Reactome,STRINGDB
GRIK1
Tclin
Family:  IC
Novelty:  0.00283685
Score:  0.973
Data Source:  Reactome,STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.952
Data Source:  Reactome,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
Score:  0.938
Data Source:  Reactome,STRINGDB
DLG1
Tbio
Novelty:  0.0050926
Score:  0.925
Data Source:  STRINGDB
GRIK5
Tclin
Family:  IC
Novelty:  0.00346213
Score:  0.909
Data Source:  STRINGDB
NCALD
Tbio
Novelty:  0.03665351
Score:  0.903
Data Source:  STRINGDB
MARK4
Tchem
Family:  Kinase
Novelty:  0.01908376
Score:  0.808
Data Source:  STRINGDB
GRM4
Tchem
Family:  GPCR
Novelty:  0.00380434
Score:  0.792
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Ionotropic activity of kainate receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of kainate receptors upon glutamate binding
Ionotropic activity of kainate receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
7
9
10
95.6
mathematical ability
3
4
5
62
1
1
0
1.1
49.5
self reported educational attainment
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
10
95.6
mathematical ability
5
62
0
1.1
49.5
self reported educational attainment
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor kainate type subunit 4
VGNC:50382
451620
Macaque
glutamate ionotropic receptor kainate type subunit 4
706383
Mouse
MGI:95817
110637
Rat
RGD:2734
24406
Dog
glutamate ionotropic receptor kainate type subunit 4
VGNC:41489
610429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor kainate type subunit 4
Macaque
glutamate ionotropic receptor kainate type subunit 4
Mouse
Rat
Dog
glutamate ionotropic receptor kainate type subunit 4
Publication Statistics
PubMed Score 288.92
PubMed score by year
PubTator Score 87.21
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Text