Tbio HSPB2 Heat shock protein beta-2

Protein Summary

Description

May regulate the kinase DMPK. The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• Q16082
• Q6I9U7
• HspB2

Gene Name

• HSPB2

Ensembl ID

• ENST00000304298
• ENSP00000302476
• ENSG00000170276

Symbol

• MKBP
• HSP27
• Hs.78846
• LOH11CR1K

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
PubMedID	0.79
cell type or tissue	0.73
biological term	0.68
co-expressed gene	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1044.76   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 504   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1044.76   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0