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Tbio
ZYX
Zyxin

Protein Summary
Description
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322764
  • ENSP00000324422
  • ENSG00000159840
  • ENST00000392910
  • ENSP00000376642
  • ENST00000645637
  • ENSP00000495629
  • ENSG00000285443
  • ENST00000646695
  • ENSP00000494798

Symbol
  • ESP-2
  • HED-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
PubMedID
0.91
cellular component
0.85
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.05   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.05   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
1
3
84
basophil count
3
1
3
84
monocyte count
1
1
1
76
monocyte count
1
1
1
76
basophil percentage of leukocytes
1
1
1
63.2
Items per page:
1 – 5 of 8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
84
basophil count
3
84
monocyte count
1
76
monocyte count
1
76
basophil percentage of leukocytes
1
63.2
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (143)
1 – 10 of 143
CCAR1
Tbio
Novelty: 0.03257229
p_int: 0.999996189
p_ni: 0.000003811
Score: 0.854
Data Source: BioPlex,STRINGDB
TANC2
Tdark
Novelty: 0.08495328
p_int: 0.99999284
p_ni: 0.00000716
Score: 0.369
Data Source: BioPlex,STRINGDB
VASP
Tbio
Novelty: 0.00041984
p_int: 0.999989557
p_ni: 0.000010443
Score: 0.998
Data Source: BioPlex,STRINGDB
ENAH
Tbio
Novelty: 0.02329247
p_int: 0.999973444
p_ni: 0.000026556
Score: 0.839
Data Source: BioPlex,STRINGDB
FKBP15
Tbio
Novelty: 0.0570695
p_int: 0.999973394
p_ni: 0.000026606
Score: 0.185
Data Source: BioPlex,STRINGDB
SECISBP2L
Tdark
Novelty: 0.03341871
p_int: 0.999951086
p_ni: 0.000048155
p_wrong: 7.59e-7
Score: 0.214
Data Source: BioPlex,STRINGDB
ZFR
Tbio
Novelty: 0.01859772
p_int: 0.999688391
p_ni: 0.000311609
Score: 0.179
Data Source: BioPlex,STRINGDB
CDPF1
Tdark
Novelty: 0.85714286
p_int: 0.998642402
p_ni: 0.001357597
p_wrong: 1e-9
Data Source: BioPlex
TUFT1
Tbio
Novelty: 0.01999031
p_int: 0.996810504
p_ni: 0.003189476
p_wrong: 2e-8
Score: 0.5
Data Source: BioPlex,STRINGDB
FHL3
Tbio
Novelty: 0.11505924
p_int: 0.996381109
p_ni: 0.003618891
Score: 0.34
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  270.05

PubMed score by year
PubTator Score  89.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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