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Tbio
ZFHX3
Zinc finger homeobox protein 3

Protein Summary
Description
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast can ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268489
  • ENSP00000268489
  • ENSG00000140836
  • ENST00000397992
  • ENSP00000438926
  • ENST00000641206
  • ENSP00000493252

Symbol
  • ATBF1
  • ATBT
  • ATBF1
  • ZNF927
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
protein domain
0.92
transcription factor perturbation
0.84
PubMedID
0.8
transcription factor binding site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.37   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.37   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
13
6
0
1.2
98.9
apolipoprotein B measurement
1
3
3
83.6
low density lipoprotein cholesterol measurement
1
2
2
82
heel bone mineral density
2
3
3
77.8
total cholesterol measurement
1
3
3
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.9
apolipoprotein B measurement
3
83.6
low density lipoprotein cholesterol measurement
2
82
heel bone mineral density
3
77.8
total cholesterol measurement
3
75.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger homeobox 3
VGNC:13813
468024
Macaque
zinc finger homeobox 3
706074
Mouse
MGI:99948
11906
Rat
RGD:1560268
307829
Dog
zinc finger homeobox 3
VGNC:48607
489729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger homeobox 3
Macaque
zinc finger homeobox 3
Mouse
Rat
Dog
zinc finger homeobox 3
Protein Structure (3 Structures, 13 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX3 regulates CDKN1A transcription
Reactome
Transcriptional regulation by RUNX3
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX3 regulates CDKN1A transcription
Transcriptional regulation by RUNX3
Gene Ontology Terms (28)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (54)
1 – 10 of 54
RUNX3
Tbio
Family:  TF
Novelty:  0.00144472
Score:  0.921
Data Source:  Reactome,STRINGDB
CDKN1A
Tchem
Family:  Enzyme
Novelty:  0.00033009
Score:  0.918
Data Source:  STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.9
Data Source:  STRINGDB
PITX2
Tbio
Family:  TF
Novelty:  0.00216568
Score:  0.829
Data Source:  STRINGDB
PIAS3
Tbio
Family:  TF
Novelty:  0.01380668
Score:  0.807
Data Source:  STRINGDB
AFP
Tbio
Novelty:  0.00004755
Score:  0.708
Data Source:  STRINGDB
PPP1R14C
Tbio
Family:  Enzyme
Novelty:  0.04635786
Score:  0.707
Data Source:  STRINGDB
MIPOL1
Tbio
Novelty:  0.2456
Score:  0.698
Data Source:  STRINGDB
KCNN3
Tchem
Family:  IC
Novelty:  0.00227544
Score:  0.68
Data Source:  STRINGDB
TRIM25
Tbio
Family:  Enzyme
Novelty:  0.0045864
Score:  0.657
Data Source:  STRINGDB
Publication Statistics
PubMed Score  122.37

PubMed score by year
PubTator Score  64.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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