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Tclin
EZH2
Histone-lysine N-methyltransferase EZH2

Protein Summary
Description
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320356
  • ENSP00000320147
  • ENSG00000106462
  • ENST00000350995
  • ENSP00000223193
  • ENST00000460911
  • ENSP00000419711
  • ENST00000476773
  • ENSP00000419050
  • ENST00000478654
  • ENSP00000417062
  • ENST00000483967
  • ENSP00000419856

Symbol
  • KMT6
  • WVS
  • ENX1
  • KMT6
  • WVS2
  • ENX-1
  • EZH2b
  • KMT6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.91
transcription factor binding site profile
0.87
histone modification site profile
0.83
transcription factor
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2867.71   (req: < 5)
Gene RIFs: 1246   (req: <= 3)
Antibodies: 763   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2867.71   (req: >= 5)
Gene RIFs: 1246   (req: > 3)
Antibodies: 763   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 445
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1