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Tclin
EZH2
Histone-lysine N-methyltransferase EZH2

Protein Summary
Description
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320356
  • ENSP00000320147
  • ENSG00000106462
  • ENST00000350995
  • ENSP00000223193
  • ENST00000460911
  • ENSP00000419711
  • ENST00000476773
  • ENSP00000419050
  • ENST00000478654
  • ENSP00000417062
  • ENST00000483967
  • ENSP00000419856

Symbol
  • KMT6
  • WVS
  • ENX1
  • KMT6
  • WVS2
  • ENX-1
  • EZH2b
  • KMT6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.91
transcription factor binding site profile
0.87
histone modification site profile
0.83
transcription factor
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2339.42   (req: < 5)
Gene RIFs: 804   (req: <= 3)
Antibodies: 763   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2339.42   (req: >= 5)
Gene RIFs: 804   (req: > 3)
Antibodies: 763   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 291
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
tazemetostat
chemical structure image
Active Ligands (291)
1 – 10 of 291
CHEMBL418052
chemical structure image
CHEMBL2204995
chemical structure image
CHEMBL3264781
chemical structure image
CHEMBL3264775
chemical structure image
CHEMBL3946272
chemical structure image
CHEMBL3394231
chemical structure image
CHEMBL3701036
chemical structure image
CHEMBL3264777
chemical structure image
CHEMBL3605451
chemical structure image
CHEMBL3264776
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
13.2
mean reticulocyte volume
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
13.2
mean reticulocyte volume
1
8.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enhancer of zeste 2 polycomb repressive complex 2 subunit
VGNC:4343
745437
Macaque
enhancer of zeste 2 polycomb repressive complex 2 subunit
709075
Mouse
MGI:107940
14056
Rat
RGD:1595860
312299
Dog
enhancer of zeste 2 polycomb repressive complex 2 subunit
VGNC:40541
475511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enhancer of zeste 2 polycomb repressive complex 2 subunit
Macaque
enhancer of zeste 2 polycomb repressive complex 2 subunit
Mouse
Rat
Dog
enhancer of zeste 2 polycomb repressive complex 2 subunit
Protein Structure (20 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15910-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (57)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (640)
1 – 10 of 640
EPOP
Tdark
Novelty: 0.06087869
p_int: 0.999999994
p_ni: 1e-9
p_wrong: 5e-9
Score: 0.766
Data Source: BioPlex,STRINGDB
JARID2
Tbio
Family: TF; Epigenetic
Novelty: 0.00921097
p_int: 0.99999999
p_ni: 5e-9
p_wrong: 4e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
MTF2
Tbio
Family: Epigenetic
Novelty: 0.01152147
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
PHF1
Tbio
Family: Epigenetic
Novelty: 0.00430297
p_int: 0.999999944
p_ni: 5.2e-8
p_wrong: 3e-9
Score: 0.977
Data Source: BioPlex,Reactome,STRINGDB
SUZ12
Tbio
Novelty: 0.00402353
p_int: 0.999999904
p_ni: 6.5e-8
p_wrong: 3.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PHF19
Tbio
Family: Epigenetic
Novelty: 0.02289037
p_int: 0.999999896
p_ni: 1.02e-7
p_wrong: 3e-9
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
EED
Tchem
Novelty: 0.00615758
p_int: 0.999999645
p_ni: 3.55e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AEBP2
Tbio
Novelty: 0.05974483
p_int: 0.999999498
p_ni: 5e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999996686
p_ni: 0.000003314
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.998880473
p_ni: 0.001045798
p_wrong: 0.000073729
Score: 0.544
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2339.42

PubMed score by year
PubTator Score  1207.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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