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Tbio
RAB11B
Ras-related protein Rab-11B

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328024
  • ENSP00000333547
  • ENSG00000185236
  • ENST00000594216
  • ENSP00000471148

Symbol
  • YPT3
  • H-YPT3
  • NDAGSCW
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
interacting protein
0.97
molecular function
0.96
cellular component
0.86
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.55   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.55   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
2
4
81.7
sleep duration
1
1
1
42
reticulocyte measurement
2
1
2
36.9
reticulocyte count
1
1
1
31.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
81.7
sleep duration
1
42
reticulocyte measurement
2
36.9
reticulocyte count
1
31.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB11B, member RAS oncogene family
VGNC:7568
743711
Macaque
RAB11B, member RAS oncogene family
707462
Mouse
MGI:99425
19326
Rat
RGD:68369
79434
Dog
RAB11B, member RAS oncogene family
VGNC:45249
611619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB11B, member RAS oncogene family
Macaque
RAB11B, member RAS oncogene family
Mouse
Rat
Dog
RAB11B, member RAS oncogene family
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15907-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Reactome
Rab regulation of trafficking
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Rab regulation of trafficking
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (185)
1 – 10 of 185
RAB11FIP2
Tbio
Novelty: 0.06330621
p_int: 1
Score: 0.98
Data Source: BioPlex,STRINGDB
RAB11FIP5
Tbio
Novelty: 0.0264203
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.94
Data Source: BioPlex,STRINGDB
RAB11FIP1
Tbio
Novelty: 0.0445306
p_int: 0.999999796
p_ni: 2.04e-7
Score: 0.947
Data Source: BioPlex,STRINGDB
SH3BP5
Tbio
Novelty: 0.00597871
p_int: 0.999993218
p_ni: 3.9e-8
p_wrong: 0.000006744
Score: 0.312
Data Source: BioPlex,STRINGDB
RAB25
Tbio
Family: Enzyme
Novelty: 0.01889483
p_int: 0.999983683
p_ni: 0.00000568
p_wrong: 0.000010637
Score: 0.922
Data Source: BioPlex,STRINGDB
DNPEP
Tchem
Family: Enzyme
Novelty: 0.02415651
p_int: 0.999969764
p_ni: 0.000030174
p_wrong: 6.2e-8
Score: 0.199
Data Source: BioPlex,STRINGDB
LYG2
Tbio
Family: Enzyme
Novelty: 0.12091256
p_int: 0.999955958
p_ni: 0.000044042
Data Source: BioPlex
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
p_int: 0.999912838
p_ni: 0.00008716
p_wrong: 2e-9
Score: 0.927
Data Source: BioPlex,STRINGDB
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.999877839
p_ni: 0.000122146
p_wrong: 1.4e-8
Data Source: BioPlex
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.99984571
p_ni: 0.000154289
p_wrong: 1e-9
Score: 0.927
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  179.55

PubMed score by year
PubTator Score  16.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer