You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
VPS72
Vacuolar protein sorting-associated protein 72 homolog

Protein Summary
Description
Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative spli ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354473
  • ENSP00000346464
  • ENSG00000163159
  • ENST00000368892
  • ENSP00000357887

Symbol
  • TCFL1
  • YL1
  • YL1
  • CFL1
  • Swc2
  • YL-1
  • TCFL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
hub protein
0.96
kinase
0.94
co-expressed gene
0.82
transcription factor binding site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
78.9
1
1
0
100
76.6
monocyte percentage of leukocytes
1
1
1
60.5
vitamin D measurement
1
1
1
59
age at first sexual intercourse measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
78.9
0
100
76.6
monocyte percentage of leukocytes
1
60.5
vitamin D measurement
1
59
age at first sexual intercourse measurement
1
33.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vacuolar protein sorting 72 homolog
VGNC:9909
749187
Macaque
vacuolar protein sorting 72 homolog
709818
Mouse
MGI:1202305
21427
Rat
RGD:1306121
310661
Dog
vacuolar protein sorting 72 homolog
VGNC:48299
475843
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vacuolar protein sorting 72 homolog
Macaque
vacuolar protein sorting 72 homolog
Mouse
Rat
Dog
vacuolar protein sorting 72 homolog
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15906-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (96)
1 – 10 of 96
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999999971
p_ni:  2.3e-8
p_wrong:  6e-9
Score:  0.953
Data Source:  BioPlex,STRINGDB
ZNHIT1
Tbio
Novelty:  0.00390514
p_int:  0.999999864
p_ni:  1.36e-7
Score:  0.93
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999998562
p_ni:  0.000001438
Score:  0.545
Data Source:  BioPlex,STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
p_int:  0.999998524
p_ni:  0.000001476
Score:  0.999
Data Source:  BioPlex,STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.999995821
p_ni:  0.000004179
Score:  0.994
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999993763
p_ni:  0.000006235
p_wrong:  2e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.999981285
p_ni:  0.000018714
p_wrong:  1e-9
Score:  0.547
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.999962183
p_ni:  0.000037816
p_wrong:  1e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.999894995
p_ni:  0.000104477
p_wrong:  5.28e-7
Score:  0.737
Data Source:  BioPlex,STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
p_int:  0.999621897
p_ni:  0.00037809
p_wrong:  1.3e-8
Score:  0.989
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  159.85

PubMed score by year
PubTator Score  33.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: