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Tchem
ATP6AP1
V-type proton ATPase subunit S1

Protein Summary
Description
Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is nec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369762
  • ENSP00000358777
  • ENSG00000071553

Symbol
  • ATP6IP1
  • ATP6S1
  • VATPS1
  • XAP3
  • 16A
  • CF2
  • Ac45
  • XAP3
  • XAP-3
  • ATP6S1
  • VATPS1
  • ATP6IP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
kinase perturbation
0.96
cellular component
0.92
biological process
0.87
gene perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.95   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.95   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
1
3
87.7
red blood cell distribution width
1
1
1
79.3
reticulocyte measurement
1
1
1
74.6
leukocyte count
1
1
1
72.5
erythrocyte count
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
87.7
red blood cell distribution width
1
79.3
reticulocyte measurement
1
74.6
leukocyte count
1
72.5
erythrocyte count
1
70.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting accessory protein 1
VGNC:7634
740281
Macaque
ATPase H+ transporting accessory protein 1
106995374
Mouse
MGI:109629
54411
Rat
RGD:620423
83615
Dog
ATPase H+ transporting accessory protein 1
VGNC:38266
610922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting accessory protein 1
Macaque
ATPase H+ transporting accessory protein 1
Mouse
Rat
Dog
ATPase H+ transporting accessory protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15904-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (37)
Insulin receptor recycling (R-HSA-77387)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Reactome
Signal Transduction
Reactome
Signaling by Insulin receptor
Name
Explore in Pharos
Explore in Source
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Signal Transduction
Signaling by Insulin receptor
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (113)
1 – 10 of 113
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.991385974
p_ni:  0.008614026
Score:  0.989
Data Source:  BioPlex,STRINGDB
ATP6AP2
Tbio
Novelty:  0.00357665
p_int:  0.982890201
p_ni:  0.017109799
Score:  0.992
Data Source:  BioPlex,STRINGDB
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.982567303
p_ni:  0.017432697
Data Source:  BioPlex
KIAA2013
Tdark
Novelty:  0.4705158
p_int:  0.972350208
p_ni:  0.027649792
Score:  0.878
Data Source:  BioPlex,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.923622624
p_ni:  0.076377376
Score:  0.995
Data Source:  BioPlex,STRINGDB
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.902358861
p_ni:  0.097641139
Score:  0.705
Data Source:  BioPlex,STRINGDB
ATP6V0D2
Tbio
Family:  Enzyme
Novelty:  0.0354396
Score:  0.986
Data Source:  STRINGDB
ATP6V1B2
Tchem
Family:  Enzyme
Novelty:  0.01767911
Score:  0.982
Data Source:  STRINGDB
ATP6V0B
Tbio
Family:  Enzyme
Novelty:  0.06595421
Score:  0.981
Data Source:  STRINGDB
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  181.95

PubMed score by year
PubTator Score  340.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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