Tchem ATP6AP1 V-type proton ATPase subunit S1

Protein Summary

Description

Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q15904
• A6ZKI4
• Q8NBT4
• Q9H0C7
• V-ATPase subunit S1

Gene Name

• ATP6AP1

Ensembl ID

• ENST00000369762
• ENSP00000358777
• ENSG00000071553

Symbol

• ATP6IP1
• ATP6S1
• VATPS1
• XAP3
• 16A
• CF2
• Ac45
• XAP3
• XAP-3
• ATP6S1
• VATPS1
• ATP6IP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
kinase perturbation	0.96
cellular component	0.92
biological process	0.87
gene perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase Subunit S1

Protein / Hydrolase / V-type Proton Atpase Subunit S1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.63   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.63   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0