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Tchem
CACNA1E
Voltage-dependent R-type calcium channel subunit alpha-1E

Protein Summary
Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358338
  • ENSP00000351101
  • ENSG00000198216
  • ENST00000367567
  • ENSP00000356539
  • ENST00000367570
  • ENSP00000356542
  • ENST00000367573
  • ENSP00000356545
  • ENST00000621551
  • ENSP00000483914
  • ENST00000621791
  • ENSP00000481619

Symbol
  • CACH6
  • CACNL1A6
  • BII
  • CACH6
  • gm139
  • Cav2.3
  • EIEE69
  • CACNL1A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.85
virus perturbation
0.83
cell type or tissue
0.79
microRNA
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.53   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.53   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1