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Tclin
SCN9A
Sodium channel protein type 9 subunit alpha

Protein Summary
Description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784). This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303354
  • ENSP00000304748
  • ENSG00000169432
  • ENST00000409435
  • ENSP00000386330
  • ENST00000409672
  • ENSP00000386306
  • ENST00000642356
  • ENSP00000495601
  • ENST00000645907
  • ENSP00000495983

Symbol
  • NENA
  • PN1
  • ETHA
  • NENA
  • SFNP
  • FEB3B
  • NE-NA
  • GEFSP7
  • HSAN2D
  • Nav1.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
biological term
0.84
virus perturbation
0.83
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 695.96   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 695.96   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5540
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (104)
1 – 10 of 104
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
Score:  0.981
Data Source:  STRINGDB
SCN2A
Tclin
Family:  IC
Novelty:  0.0007317
Score:  0.961
Data Source:  STRINGDB
SCN3A
Tclin
Family:  IC
Novelty:  0.00646122
Score:  0.961
Data Source:  STRINGDB
SCN4B
Tbio
Family:  IC
Novelty:  0.02505113
Score:  0.958
Data Source:  STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
Score:  0.958
Data Source:  STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
Score:  0.951
Data Source:  STRINGDB
ANK3
Tbio
Novelty:  0.00429246
Score:  0.93
Data Source:  STRINGDB
ANK1
Tbio
Novelty:  0.00225305
Score:  0.924
Data Source:  STRINGDB
NFASC
Tbio
Novelty:  0.00545331
Score:  0.924
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.923
Data Source:  STRINGDB
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
1
3
61.4
1
1
0
7.4
58.4
Mesial temporal lobe epilepsy with hippocampal sclerosis
1
1
0
1.3
31.4
1
1
0
5.8
27.3
self reported educational attainment
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
61.4
0
7.4
58.4
Mesial temporal lobe epilepsy with hippocampal sclerosis
0
1.3
31.4
0
5.8
27.3
self reported educational attainment
1
21.5
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 9
VGNC:14356
459704
Macaque
sodium voltage-gated channel alpha subunit 9
574119
Mouse
MGI:107636
20274
Rat
RGD:69368
78956
Dog
sodium voltage-gated channel alpha subunit 9
VGNC:45924
100855710
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 9
Macaque
sodium voltage-gated channel alpha subunit 9
Mouse
Rat
Dog
sodium voltage-gated channel alpha subunit 9
Publication Statistics
PubMed Score 695.96
PubMed score by year
PubTator Score 357.79
PubTator score by year
Patents
Patents by year