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Tbio
USF2
Upstream stimulatory factor 2

Protein Summary
Description
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222305
  • ENSP00000222305
  • ENSG00000105698
  • ENST00000343550
  • ENSP00000340633
  • ENST00000379134
  • ENSP00000368429
  • ENST00000595068
  • ENSP00000471099

Symbol
  • BHLHB12
  • FIP
  • bHLHb12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
molecular function
0.91
disease perturbation
0.9
biological process
0.68
transcription factor binding site profile
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.72   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.72   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
84.4
mean corpuscular hemoglobin concentration
1
1
1
74.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
84.4
mean corpuscular hemoglobin concentration
1
74.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
upstream transcription factor 2, c-fos interacting
VGNC:14761
101057082
Macaque
upstream transcription factor 2, c-fos interacting
718527
Mouse
MGI:99961
22282
Dog
upstream transcription factor 2, c-fos interacting
VGNC:53999
612662
Cow
upstream transcription factor 2, c-fos interacting
407240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
upstream transcription factor 2, c-fos interacting
Macaque
upstream transcription factor 2, c-fos interacting
Mouse
Dog
upstream transcription factor 2, c-fos interacting
Cow
upstream transcription factor 2, c-fos interacting
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15853-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (83)
1 – 10 of 83
USF1
Tbio
Family: TF
Novelty: 0.00136587
p_int: 1
Score: 0.987
Data Source: BioPlex,STRINGDB
CCDC102B
Tdark
Novelty: 0.28075569
p_int: 0.999993798
p_ni: 0.000005925
p_wrong: 2.77e-7
Score: 0.181
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.998355639
p_ni: 0.000135305
p_wrong: 0.001509056
Data Source: BioPlex
FOSL2
Tbio
Family: TF
Novelty: 0.00375452
p_int: 0.997363327
p_ni: 0.002326216
p_wrong: 0.000310456
Score: 0.321
Data Source: BioPlex,STRINGDB
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.987604238
p_ni: 0.000033047
p_wrong: 0.012362715
Data Source: BioPlex
ADAMTS12
Tbio
Family: Enzyme
Novelty: 0.03184816
p_int: 0.93258839
p_ni: 0.000138513
p_wrong: 0.067273097
Score: 0.823
Data Source: BioPlex,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.957
Data Source: STRINGDB
SP1
Tbio
Family: TF
Novelty: 0.0007915
Score: 0.936
Data Source: STRINGDB
FOSL1
Tbio
Family: TF
Novelty: 0.00294254
Score: 0.924
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  179.72

PubMed score by year
PubTator Score  225.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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