You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADIPOQ
Adiponectin

Protein Classes
Protein Summary
Description
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320741
  • ENSP00000320709
  • ENSG00000181092
  • ENST00000444204
  • ENSP00000389814

Symbol
  • ACDC
  • ACRP30
  • APM1
  • GBP28
  • ACDC
  • ADPN
  • APM1
  • APM-1
  • GBP28
  • ACRP30
  • ADIPQTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
gene perturbation
1
chemical
0.99
PubMedID
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9836.48   (req: < 5)
Gene RIFs: 1963   (req: <= 3)
Antibodies: 1698   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9836.48   (req: >= 5)
Gene RIFs: 1963   (req: > 3)
Antibodies: 1698   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
3
2
3
99.5
BMI-adjusted adiponectin measurement
1
2
2
97
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adiponectin measurement
3
99.5
BMI-adjusted adiponectin measurement
2
97
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adiponectin, C1Q and collagen domain containing
VGNC:11331
471032
Macaque
adiponectin, C1Q and collagen domain containing
574212
Mouse
MGI:106675
11450
Rat
RGD:628748
246253
Dog
adiponectin, C1Q and collagen domain containing
VGNC:37656
403625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adiponectin, C1Q and collagen domain containing
Macaque
adiponectin, C1Q and collagen domain containing
Mouse
Rat
Dog
adiponectin, C1Q and collagen domain containing
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (208)
AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMPK inhibits chREBP transcriptional activation activity
Reactome
Developmental Biology
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Transcriptional regulation of white adipocyte differentiation
Name
Explore in Pharos
Explore in Source
AMPK inhibits chREBP transcriptional activation activity
Developmental Biology
Integration of energy metabolism
Metabolism
Transcriptional regulation of white adipocyte differentiation
Gene Ontology Terms (87)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Protein-Protein Interactions (367)
1 – 10 of 367
C1QTNF4
Tbio
Novelty: 0.10701626
p_int: 0.999991484
p_wrong: 0.000008516
Data Source: BioPlex
DNLZ
Tdark
Novelty: 0.10113346
p_int: 0.999950618
p_ni: 0.00004938
p_wrong: 2e-9
Data Source: BioPlex
SHARPIN
Tbio
Novelty: 0.0197352
p_int: 0.99981851
p_ni: 0.000048553
p_wrong: 0.000132937
Data Source: BioPlex
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
p_int: 0.99906667
p_ni: 0.000933101
p_wrong: 2.29e-7
Data Source: BioPlex
C1QL4
Tdark
Novelty: 0.37071722
p_int: 0.997084051
p_ni: 0.002824071
p_wrong: 0.000091878
Data Source: BioPlex
PDP1
Tbio
Family: Enzyme
Novelty: 0.00442352
p_int: 0.994541252
p_ni: 0.005458658
p_wrong: 9e-8
Data Source: BioPlex
C1QL1
Tdark
Novelty: 0.11689088
p_int: 0.992985532
p_ni: 0.005846679
p_wrong: 0.001167789
Data Source: BioPlex
COL14A1
Tbio
Novelty: 0.01760399
p_int: 0.991193932
p_ni: 0.008806066
p_wrong: 3e-9
Data Source: BioPlex
HOMER1
Tbio
Novelty: 0.00264721
p_int: 0.954101443
p_ni: 0.045875017
p_wrong: 0.000023539
Data Source: BioPlex
SEH1L
Tbio
Novelty: 0.03666501
p_int: 0.938956971
p_ni: 0.061043029
Data Source: BioPlex
Publication Statistics
PubMed Score  9836.48

PubMed score by year
PubTator Score  7090.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: