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Tbio
KCNJ8
ATP-sensitive inward rectifier potassium channel 8

Protein Summary
Description
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240662
  • ENSP00000240662
  • ENSG00000121361

Symbol
  • KIR6.1
  • uKATP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
gene perturbation
0.89
cell type or tissue
0.83
disease perturbation
0.74
cellular component
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.13   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.13   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 8
VGNC:8427
740604
Macaque
potassium voltage-gated channel subfamily J member 8
706369
Mouse
MGI:1100508
16523
Rat
RGD:2960
25472
Dog
potassium voltage-gated channel subfamily J member 8
VGNC:42268
486639
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 8
Macaque
potassium voltage-gated channel subfamily J member 8
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15842-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
ATP sensitive Potassium channels (R-HSA-1296025)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATP sensitive Potassium channels
Reactome
Inwardly rectifying K+ channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
ATP sensitive Potassium channels
Inwardly rectifying K+ channels
Neuronal System
Potassium Channels
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (86)
1 – 10 of 86
HFE
Tbio
Novelty: 0.00042077
p_int: 0.991714425
p_ni: 0.008285575
Data Source: BioPlex
CD1E
Tbio
Novelty: 0.00171622
p_int: 0.98968367
p_ni: 0.010316329
Data Source: BioPlex
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.984250647
p_ni: 0.015749353
Data Source: BioPlex
CD1A
Tbio
Novelty: 0.00090676
p_int: 0.983238195
p_ni: 0.016761804
p_wrong: 1e-9
Data Source: BioPlex
CD1B
Tbio
Novelty: 0.00102701
p_int: 0.979516028
p_ni: 0.020483972
Data Source: BioPlex
MCOLN3
Tchem
Family: IC
Novelty: 0.03209262
p_int: 0.972407764
p_ni: 0.027592236
Data Source: BioPlex
LRRC55
Tbio
Family: IC
Novelty: 0.25121277
p_int: 0.972377094
p_ni: 0.027622893
p_wrong: 1.3e-8
Data Source: BioPlex
UPK2
Tbio
Novelty: 0.01066132
p_int: 0.966664596
p_ni: 0.033335404
Data Source: BioPlex
HLA-DQA1
Tbio
Novelty: 0.00077488
p_int: 0.966262023
p_ni: 0.033737975
p_wrong: 2e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.963165811
p_ni: 0.036834189
Data Source: BioPlex
Publication Statistics
PubMed Score  264.13

PubMed score by year
PubTator Score  112.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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