Tbio KCNJ8 ATP-sensitive inward rectifier potassium channel 8

Protein Summary

Description

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q15842
• O00657

Gene Name

• KCNJ8

Ensembl ID

• ENST00000240662
• ENSP00000240662
• ENSG00000121361

Symbol

• KIR6.1
• uKATP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
gene perturbation	0.89
cell type or tissue	0.83
disease perturbation	0.74
cellular component	0.65

Protein Classes

DTO Classes

Protein / Ion Channel / Inward Rectifier-type Potassium Channel Family / Kcnj8 Subfamily / Atp-sensitive Inward Rectifier Potassium Channel 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.08   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.08   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0