You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
VAMP3
Vesicle-associated membrane protein 3

Protein Summary
Description
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000054666
  • ENSP00000054666
  • ENSG00000049245

Symbol
  • SYB3
  • CEB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
interacting protein
0.96
disease perturbation
0.93
biological process
0.92
virus perturbation
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.41   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.41   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
circadian rhythm
1
1
0
1.1
32.9
testosterone measurement
1
1
1
21.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
circadian rhythm
0
1.1
32.9
testosterone measurement
1
21.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vesicle associated membrane protein 3
VGNC:7022
457906
Macaque
vesicle associated membrane protein 3
707972
Mouse
MGI:1321389
22319
Rat
RGD:61880
29528
Dog
vesicle associated membrane protein 3
VGNC:48223
102154970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vesicle associated membrane protein 3
Macaque
vesicle associated membrane protein 3
Mouse
Rat
Dog
vesicle associated membrane protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15836-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (33)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Cargo recognition for clathrin-mediated endocytosis
Class I MHC mediated antigen processing & presentation
Clathrin-mediated endocytosis
Gene Ontology Terms (36)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (365)
1 – 10 of 365
WDFY1
Tbio
Novelty: 0.13382544
p_int: 0.999962471
p_ni: 0.000037523
p_wrong: 6e-9
Data Source: BioPlex
SYPL1
Tbio
Novelty: 0.04187055
p_int: 0.99993168
p_ni: 0.000068296
p_wrong: 2.3e-8
Score: 0.449
Data Source: BioPlex,STRINGDB
WASHC1
Tbio
Novelty: 0.09242196
p_int: 0.999867705
p_ni: 0.000132294
p_wrong: 1e-9
Data Source: BioPlex
WDFY2
Tbio
Novelty: 0.01835759
p_int: 0.999857634
p_ni: 0.000142365
p_wrong: 1e-9
Data Source: BioPlex
STX19
Tdark
Novelty: 0.99387951
p_int: 0.999489194
p_ni: 0.000510799
p_wrong: 8e-9
Score: 0.806
Data Source: BioPlex,STRINGDB
STX11
Tbio
Novelty: 0.01670743
p_int: 0.99945366
p_ni: 0.00054634
Score: 0.863
Data Source: BioPlex,STRINGDB
STX12
Tbio
Novelty: 0.03836262
p_int: 0.999142995
p_ni: 0.000857005
Score: 0.986
Data Source: BioPlex,STRINGDB
STX7
Tbio
Novelty: 0.03109969
p_int: 0.998741975
p_ni: 0.001258024
Score: 0.964
Data Source: BioPlex,STRINGDB
STX3
Tbio
Novelty: 0.01055819
p_int: 0.997818598
p_ni: 0.002181253
p_wrong: 1.5e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MICA
Tbio
Novelty: 0.03965901
p_int: 0.997253225
p_ni: 0.002746751
p_wrong: 2.4e-8
Score: 0.403
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  131.41

PubMed score by year
PubTator Score  82.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: