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Tchem
GRK1
Rhodopsin kinase

Protein Summary
Description
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335678
  • ENSP00000334876
  • ENSG00000185974

Symbol
  • RHOK
  • RK
  • RHOK
  • GPRK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.93
biological process
0.71
cellular component
0.61
hub protein
0.49


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.75   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.75   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
51.4
mean corpuscular volume
1
1
1
38.2
triglyceride measurement
1
1
1
28.1
sleep measurement
1
1
1
26.6
body height
1
1
1
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
51.4
mean corpuscular volume
1
38.2
triglyceride measurement
1
28.1
sleep measurement
1
26.6
body height
1
10.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor kinase 1
VGNC:13112
467338
Macaque
G protein-coupled receptor kinase 1
715484
Mouse
MGI:1345146
24013
Rat
RGD:619712
81760
Dog
G protein-coupled receptor kinase 1
VGNC:41501
485557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor kinase 1
Macaque
G protein-coupled receptor kinase 1
Mouse
Rat
Dog
G protein-coupled receptor kinase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15835-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (105)
1 – 10 of 105
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.999
Data Source:  Reactome,STRINGDB
RCVRN
Tbio
Novelty:  0.00266222
Score:  0.998
Data Source:  Reactome,STRINGDB
SAG
Tbio
Novelty:  0.00040944
Score:  0.988
Data Source:  STRINGDB
NCS1
Tbio
Novelty:  0.0051468
Score:  0.97
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.938
Data Source:  STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
Score:  0.909
Data Source:  STRINGDB
HPCA
Tbio
Novelty:  0.01360155
Score:  0.863
Data Source:  STRINGDB
GRK7
Tchem
Family:  Kinase
Novelty:  0.01119521
Score:  0.813
Data Source:  STRINGDB
NCALD
Tbio
Novelty:  0.03665351
Score:  0.784
Data Source:  STRINGDB
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.782
Data Source:  STRINGDB
Publication Statistics
PubMed Score  137.75

PubMed score by year
PubTator Score  104.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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