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Tbio
STXBP2
Syntaxin-binding protein 2

Protein Summary
Description
Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221283
  • ENSP00000221283
  • ENSG00000076944
  • ENST00000414284
  • ENSP00000409471
  • ENST00000441779
  • ENSP00000413606

Symbol
  • UNC18B
  • FHL5
  • UNC18B
  • Hunc18b
  • UNC18-2
  • pp10122
  • MUNC18-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
kinase perturbation
0.84
transcription factor perturbation
0.84
cellular component
0.7
gene perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.91   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.91   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
4.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 2
VGNC:2241
741963
Macaque
syntaxin binding protein 2
708676
Mouse
MGI:107370
20911
Rat
RGD:619967
81804
Dog
syntaxin binding protein 2
VGNC:46960
403880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 2
Macaque
syntaxin binding protein 2
Mouse
Rat
Dog
syntaxin binding protein 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15833-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (149)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Hemostasis
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Hemostasis
Immune System
Other interleukin signaling
Platelet activation, signaling and aggregation
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (165)
1 – 10 of 165
STX11
Tbio
Novelty: 0.01670743
p_int: 0.999999982
p_ni: 1.8e-8
p_wrong: 1e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
STX19
Tdark
Novelty: 0.99387951
p_int: 0.999999925
p_ni: 7.5e-8
Score: 0.647
Data Source: BioPlex,STRINGDB
STX3
Tbio
Novelty: 0.01055819
p_int: 0.999998556
p_ni: 0.000001444
Score: 0.935
Data Source: BioPlex,STRINGDB
SPATA24
Tdark
Novelty: 0.95478351
p_int: 0.999966015
p_ni: 0.000033985
Score: 0.165
Data Source: BioPlex,STRINGDB
TUSC3
Tbio
Novelty: 0.01388722
p_int: 0.999538132
p_ni: 0.000461866
p_wrong: 2e-9
Score: 0.215
Data Source: BioPlex,STRINGDB
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00893083
p_int: 0.999534358
p_ni: 0.000465642
Data Source: BioPlex
S100A4
Tbio
Novelty: 0.00136919
p_int: 0.999040296
p_ni: 0.000959686
p_wrong: 1.8e-8
Data Source: BioPlex
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
p_int: 0.98345631
p_ni: 0.01654354
p_wrong: 1.5e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
PHTF2
Tdark
Novelty: 0.52825058
p_int: 0.979536267
p_ni: 0.0167843
p_wrong: 0.003679433
Data Source: BioPlex
SLC25A41
Tdark
Family: Transporter
Novelty: 1.04918395
p_int: 0.969244184
p_ni: 0.030717368
p_wrong: 0.000038447
Data Source: BioPlex
Publication Statistics
PubMed Score  57.91

PubMed score by year
PubTator Score  34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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