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Tbio
STXBP2
Syntaxin-binding protein 2

Protein Summary
Description
Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells. This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221283
  • ENSP00000221283
  • ENSG00000076944
  • ENST00000414284
  • ENSP00000409471
  • ENST00000441779
  • ENSP00000413606

Symbol
  • UNC18B
  • FHL5
  • UNC18B
  • Hunc18b
  • UNC18-2
  • pp10122
  • MUNC18-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
kinase perturbation
0.84
transcription factor perturbation
0.84
cellular component
0.7
gene perturbation
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.22   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.22   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (165)
STX11
Tbio
Novelty:  0.01670743
p_int:  0.999999982
p_ni:  1.8e-8
p_wrong:  1e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
STX19
Tdark
Novelty:  0.99387951
p_int:  0.999999925
p_ni:  7.5e-8
Score:  0.647
Data Source:  BioPlex,STRINGDB
STX3
Tbio
Novelty:  0.01055819
p_int:  0.999998556
p_ni:  0.000001444
Score:  0.935
Data Source:  BioPlex,STRINGDB
SPATA24
Tdark
Novelty:  0.95478351
p_int:  0.999966015
p_ni:  0.000033985
Score:  0.165
Data Source:  BioPlex,STRINGDB
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.999538132
p_ni:  0.000461866
p_wrong:  2e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.999534358
p_ni:  0.000465642
Data Source:  BioPlex
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999040296
p_ni:  0.000959686
p_wrong:  1.8e-8
Data Source:  BioPlex
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
p_int:  0.98345631
p_ni:  0.01654354
p_wrong:  1.5e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
PHTF2
Tdark
Novelty:  0.52825058
p_int:  0.979536267
p_ni:  0.0167843
p_wrong:  0.003679433
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.969244184
p_ni:  0.030717368
p_wrong:  0.000038447
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (149)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Hemostasis
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Hemostasis
Immune System
Other interleukin signaling
Platelet activation, signaling and aggregation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
resistin measurement
1
2
0
6.2
96.9
CD209 antigen measurement
2
3
3
85.1
blood protein measurement
1
2
2
82.2
low affinity immunoglobulin epsilon Fc receptor measurement
1
1
1
50.5
neuropathic pain
1
1
0
1.7
16.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
resistin measurement
0
6.2
96.9
CD209 antigen measurement
3
85.1
blood protein measurement
2
82.2
low affinity immunoglobulin epsilon Fc receptor measurement
1
50.5
neuropathic pain
0
1.7
16.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 2
VGNC:2241
741963
Macaque
syntaxin binding protein 2
708676
Mouse
MGI:107370
20911
Rat
RGD:619967
81804
Dog
syntaxin binding protein 2
VGNC:46960
403880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 2
Macaque
syntaxin binding protein 2
Mouse
Rat
Dog
syntaxin binding protein 2
Publication Statistics
PubMed Score 73.22
PubMed score by year
PubTator Score 34.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title