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Tchem
STK11
Serine/threonine-protein kinase STK11

Protein Summary
Description
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA da ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326873
  • ENSP00000324856
  • ENSG00000118046

Symbol
  • LKB1
  • PJS
  • PJS
  • LKB1
  • hLKB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase
1
molecular function
1
biological term
0.99
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1594.58   (req: < 5)
Gene RIFs: 356   (req: <= 3)
Antibodies: 1199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1594.58   (req: >= 5)
Gene RIFs: 356   (req: > 3)
Antibodies: 1199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (250)
STRADB
Tbio
Family:  Kinase
Novelty:  0.03532206
p_int:  1
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
STRADA
Tbio
Family:  Kinase
Novelty:  0.0190243
p_int:  0.999999963
p_ni:  5e-9
p_wrong:  3.2e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
KDM4A
Tchem
Family:  Epigenetic
Novelty:  0.00643043
p_int:  0.999998658
p_ni:  0.000001342
p_wrong:  1e-9
Score:  0.246
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.999998158
p_ni:  0.000001822
p_wrong:  2e-8
Data Source:  BioPlex
HSP90AB3P
Tdark
p_int:  0.999997121
p_ni:  0.000002879
Data Source:  BioPlex
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999994711
p_ni:  0.000005289
Score:  0.205
Data Source:  BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int:  0.999990892
p_ni:  0.000009105
p_wrong:  2e-9
Data Source:  BioPlex
CAB39L
Tbio
Novelty:  0.15875148
p_int:  0.999980628
p_ni:  0.000019364
p_wrong:  9e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.999962513
p_ni:  0.000037242
p_wrong:  2.44e-7
Score:  0.6
Data Source:  BioPlex,STRINGDB
CAB39
Tbio
Novelty:  0.01592402
p_int:  0.999801199
p_ni:  0.000198801
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
Pathways (90)
AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

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Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMPK inhibits chREBP transcriptional activation activity
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell death genes
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
AMPK inhibits chREBP transcriptional activation activity
Energy dependent regulation of mTOR by LKB1-AMPK
FOXO-mediated transcription
FOXO-mediated transcription of cell death genes
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
9
10
98.8
heel bone mineral density
3
5
8
98.1
serum non-albumin protein measurement
1
6
6
95.3
reticulocyte measurement
3
3
3
94.2
lymphocyte percentage of leukocytes
2
4
4
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
10
98.8
heel bone mineral density
8
98.1
serum non-albumin protein measurement
6
95.3
reticulocyte measurement
3
94.2
lymphocyte percentage of leukocytes
4
93.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 11
VGNC:6653
468641
Macaque
serine/threonine-protein kinase STK11 [Source:RefSeq peptide;Acc:NP_001248599]
Mouse
MGI:1341870
20869
Rat
RGD:1308653
314621
Dog
serine/threonine kinase 11
VGNC:54369
485088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 11
Macaque
serine/threonine-protein kinase STK11 [Source:RefSeq peptide;Acc:NP_001248599]
Mouse
Rat
Dog
serine/threonine kinase 11
Publication Statistics
PubMed Score 1594.58
PubMed score by year
PubTator Score 827.17
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title