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Tchem
STK11
Serine/threonine-protein kinase STK11

Protein Summary
Description
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA da ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326873
  • ENSP00000324856
  • ENSG00000118046

Symbol
  • LKB1
  • PJS
  • PJS
  • LKB1
  • hLKB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase
1
molecular function
1
biological term
0.99
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1545.06   (req: < 5)
Gene RIFs: 356   (req: <= 3)
Antibodies: 1199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1545.06   (req: >= 5)
Gene RIFs: 356   (req: > 3)
Antibodies: 1199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
2
2
77.6
1
1
1
55.1
lymphocyte count
1
1
1
44.3
monocyte count
1
1
1
44.3
lymphocyte percentage of leukocytes
1
1
1
43.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
77.6
1
55.1
lymphocyte count
1
44.3
monocyte count
1
44.3
lymphocyte percentage of leukocytes
1
43.7
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (90)
AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMPK inhibits chREBP transcriptional activation activity
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell death genes
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
AMPK inhibits chREBP transcriptional activation activity
Energy dependent regulation of mTOR by LKB1-AMPK
FOXO-mediated transcription
FOXO-mediated transcription of cell death genes
Gene expression (Transcription)
Gene Ontology Terms (49)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (250)
1 – 10 of 250
STRADB
Tbio
Family: Kinase
Novelty: 0.03532206
p_int: 1
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
STRADA
Tbio
Family: Kinase
Novelty: 0.0190243
p_int: 0.999999963
p_ni: 5e-9
p_wrong: 3.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KDM4A
Tchem
Family: Epigenetic
Novelty: 0.00643043
p_int: 0.999998658
p_ni: 0.000001342
p_wrong: 1e-9
Score: 0.246
Data Source: BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int: 0.999998158
p_ni: 0.000001822
p_wrong: 2e-8
Data Source: BioPlex
HSP90AB3P
Tdark
p_int: 0.999997121
p_ni: 0.000002879
Data Source: BioPlex
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999994711
p_ni: 0.000005289
Score: 0.205
Data Source: BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int: 0.999990892
p_ni: 0.000009105
p_wrong: 2e-9
Data Source: BioPlex
CAB39L
Tbio
Novelty: 0.15875148
p_int: 0.999980628
p_ni: 0.000019364
p_wrong: 9e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
C5orf24
Tdark
Novelty: 3.95177775
p_int: 0.999962513
p_ni: 0.000037242
p_wrong: 2.44e-7
Score: 0.6
Data Source: BioPlex,STRINGDB
CAB39
Tbio
Novelty: 0.01592402
p_int: 0.999801199
p_ni: 0.000198801
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  1545.06

PubMed score by year
PubTator Score  827.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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