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Tchem
CHRNA6
Neuronal acetylcholine receptor subunit alpha-6

Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276410
  • ENSP00000276410
  • ENSG00000147434
  • ENST00000534622
  • ENSP00000433871

Symbol
  • CHNRA6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.84
cell line
0.62
transcription factor perturbation
0.54
small molecule perturbation
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.87   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.87   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (53)
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
Score:  0.933
Data Source:  Reactome,STRINGDB
CHRNB2
Tclin
Family:  IC
Novelty:  0.01251655
Score:  0.932
Data Source:  STRINGDB
CHRNA5
Tbio
Family:  IC
Novelty:  0.00425291
Score:  0.929
Data Source:  STRINGDB
CHRNA7
Tchem
Family:  IC
Novelty:  0.00590784
Score:  0.924
Data Source:  STRINGDB
CHRNB3
Tchem
Family:  IC
Novelty:  0.031456
Score:  0.914
Data Source:  Reactome,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
Score:  0.907
Data Source:  STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.906
Data Source:  Reactome,STRINGDB
CHRNA2
Tchem
Family:  IC
Novelty:  0.02542208
Score:  0.905
Data Source:  STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
Score:  0.904
Data Source:  STRINGDB
CHRNA1
Tclin
Family:  IC
Novelty:  0.01393364
Score:  0.903
Data Source:  STRINGDB
Pathways (14)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
3
3
3
91.7
1
1
1
33.1
tobacco smoke exposure measurement
1
1
1
21.5
smoking cessation
2
1
2
12.8
smoking behavior
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
3
91.7
1
33.1
tobacco smoke exposure measurement
1
21.5
smoking cessation
2
12.8
smoking behavior
1
4.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 6 subunit
VGNC:7591
472750
Macaque
cholinergic receptor nicotinic alpha 6 subunit
705725
Mouse
MGI:106213
11440
Rat
RGD:69281
81721
Dog
cholinergic receptor nicotinic alpha 6 subunit
VGNC:39240
482836
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 6 subunit
Macaque
cholinergic receptor nicotinic alpha 6 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic alpha 6 subunit
Publication Statistics
PubMed Score 23.87
PubMed score by year
PubTator Score 13.42
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title