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Tchem
CHRNA2
Neuronal acetylcholine receptor subunit alpha-2

Protein Classes
Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240132
  • ENSP00000240132
  • ENSG00000120903
  • ENST00000407991
  • ENSP00000385026
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
drug
0.85
protein domain
0.85
disease perturbation
0.68
gene perturbation
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.19   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.19   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
4
5
96.8
smoking initiation
4
5
5
94.8
cigarettes per day measurement
4
3
4
75.2
smoking cessation
2
2
3
74.6
smoking behavior
1
1
1
74.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
5
96.8
smoking initiation
5
94.8
cigarettes per day measurement
4
75.2
smoking cessation
3
74.6
smoking behavior
1
74.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 2 subunit
VGNC:7589
472725
Macaque
cholinergic receptor nicotinic alpha 2 subunit
712868
Mouse
MGI:87886
110902
Rat
RGD:621533
170945
Dog
cholinergic receptor nicotinic alpha 2 subunit
VGNC:39237
486101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 2 subunit
Macaque
cholinergic receptor nicotinic alpha 2 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic alpha 2 subunit
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15822-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Protein-Protein Interactions (67)
1 – 10 of 67
CHRNB2
Tclin
Family:  IC
Novelty:  0.01251655
Score:  0.96
Data Source:  STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
Score:  0.958
Data Source:  STRINGDB
CHRNA5
Tbio
Family:  IC
Novelty:  0.00425291
Score:  0.942
Data Source:  STRINGDB
CHRNA7
Tchem
Family:  IC
Novelty:  0.00590784
Score:  0.924
Data Source:  STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
Score:  0.91
Data Source:  STRINGDB
CHRNB3
Tchem
Family:  IC
Novelty:  0.031456
Score:  0.908
Data Source:  Reactome,STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.906
Data Source:  STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
Score:  0.905
Data Source:  STRINGDB
CHRNA6
Tchem
Family:  IC
Novelty:  0.03991261
Score:  0.905
Data Source:  STRINGDB
CHRNA1
Tclin
Family:  IC
Novelty:  0.01393364
Score:  0.904
Data Source:  STRINGDB
Publication Statistics
PubMed Score  39.19

PubMed score by year
PubTator Score  22.62

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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