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Tbio
UBE2V2
Ubiquitin-conjugating enzyme E2 variant 2

Protein Summary
Description
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000523111
  • ENSP00000428209
  • ENSG00000169139

Symbol
  • MMS2
  • UEV2
  • MMS2
  • UEV2
  • EDPF1
  • UEV-2
  • DDVIT1
  • EDAF-1
  • EDPF-1
  • DDVit-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
biological process
0.87
histone modification site profile
0.84
kinase perturbation
0.81
virus perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.65   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.65   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (513)
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.999
Data Source:  Reactome,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.999
Data Source:  STRINGDB
UBE2B
Tchem
Novelty:  0.01578275
Score:  0.996
Data Source:  Reactome,STRINGDB
HLTF
Tbio
Family:  Enzyme
Novelty:  0.01177896
Score:  0.996
Data Source:  Reactome,STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.996
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.996
Data Source:  STRINGDB
RAD18
Tbio
Family:  Enzyme
Novelty:  0.00519213
Score:  0.995
Data Source:  Reactome,STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.993
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.989
Data Source:  Reactome,STRINGDB
SHPRH
Tbio
Family:  Epigenetic
Novelty:  0.04914227
Score:  0.988
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Cell Cycle
Cell Cycle Checkpoints
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
81.9
mean corpuscular volume
1
1
1
75
red blood cell density measurement
1
1
1
73.2
eosinophil percentage of leukocytes
1
1
1
49.5
basophil count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
81.9
mean corpuscular volume
1
75
red blood cell density measurement
1
73.2
eosinophil percentage of leukocytes
1
49.5
basophil count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin conjugating enzyme E2 V2
714735
Mouse
MGI:1917870
70620
Rat
RGD:727838
287927
Dog
ubiquitin conjugating enzyme E2 V2
VGNC:49665
608470
Cow
ubiquitin conjugating enzyme E2 V2
VGNC:36597
286803
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin conjugating enzyme E2 V2
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 V2
Cow
ubiquitin conjugating enzyme E2 V2
Publication Statistics
PubMed Score 90.65
PubMed score by year
PubTator Score 34.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title