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Tbio
UBE2V2
Ubiquitin-conjugating enzyme E2 variant 2

Protein Summary
Description
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000523111
  • ENSP00000428209
  • ENSG00000169139

Symbol
  • MMS2
  • UEV2
  • MMS2
  • UEV2
  • EDPF1
  • UEV-2
  • DDVIT1
  • EDAF-1
  • EDPF-1
  • DDVit-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
biological process
0.87
histone modification site profile
0.84
kinase perturbation
0.81
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.84   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.84   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Cell Cycle
Cell Cycle Checkpoints
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (513)
1 – 10 of 513
UBE2N
Tbio
Novelty: 0.00723255
Score: 0.999
Data Source: Reactome,STRINGDB
UBC
Tbio
Novelty: 0.00161137
Score: 0.999
Data Source: STRINGDB
UBE2B
Tbio
Novelty: 0.02464704
Score: 0.996
Data Source: Reactome,STRINGDB
HLTF
Tbio
Family: Enzyme
Novelty: 0.01410809
Score: 0.996
Data Source: Reactome,STRINGDB
UBB
Tbio
Novelty: 0.00895161
Score: 0.996
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.996
Data Source: STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00575302
Score: 0.995
Data Source: Reactome,STRINGDB
STUB1
Tbio
Family: Enzyme
Novelty: 0.00091876
Score: 0.993
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00316288
Score: 0.989
Data Source: Reactome,STRINGDB
SHPRH
Tbio
Family: Epigenetic
Novelty: 0.08559201
Score: 0.988
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  56.84

PubMed score by year
PubTator Score  34.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer