You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NPTX1
Neuronal pentraxin-1

Protein Summary
Description
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306773
  • ENSP00000307549
  • ENSG00000171246

Symbol
  • NP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
PubMedID
0.82
microRNA
0.75
gene perturbation
0.72
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.97   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.97   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
NPTX2
Tbio
Novelty:  0.00686292
p_int:  0.999919176
p_ni:  0.000080824
Data Source:  BioPlex
NECTIN3
Tbio
Novelty:  0.01288113
p_int:  0.999802626
p_ni:  0.000197374
Score:  0.154
Data Source:  BioPlex,STRINGDB
TCTN1
Tbio
Novelty:  0.0657704
p_int:  0.995911162
p_ni:  0.004088838
Data Source:  BioPlex
CD160
Tbio
Novelty:  0.01511748
p_int:  0.994908817
p_ni:  0.005091183
Data Source:  BioPlex
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.994908817
p_ni:  0.005091183
Data Source:  BioPlex
WNT7A
Tbio
Novelty:  0.00421662
p_int:  0.994287707
p_ni:  0.005712293
Score:  0.228
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.994204671
p_ni:  0.005795329
Data Source:  BioPlex
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.993743615
p_ni:  0.006256367
p_wrong:  1.8e-8
Data Source:  BioPlex
LYPD1
Tbio
Novelty:  0.10740408
p_int:  0.9880076
p_ni:  0.011992399
p_wrong:  1e-9
Score:  0.24
Data Source:  BioPlex,STRINGDB
CD96
Tbio
Novelty:  0.02087722
p_int:  0.987527411
p_ni:  0.012472588
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
2
3
45.6
thalamus volume
1
1
0
6.4
44.2
pulse pressure measurement
1
1
1
40.7
aspartate aminotransferase measurement
1
1
0
6.2
38.8
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
3
45.6
thalamus volume
0
6.4
44.2
pulse pressure measurement
1
40.7
aspartate aminotransferase measurement
0
6.2
38.8
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal pentraxin 1
VGNC:9480
468350
Macaque
neuronal pentraxin 1
718259
Mouse
MGI:107811
18164
Rat
RGD:628894
266777
Dog
neuronal pentraxin 1
VGNC:43933
483356
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal pentraxin 1
Macaque
neuronal pentraxin 1
Mouse
Rat
Dog
neuronal pentraxin 1
Publication Statistics
PubMed Score 43.97
PubMed score by year
PubTator Score 155.39
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title