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Tbio
TBCC
Tubulin-specific chaperone C

Protein Classes
Protein Summary
Description
Tubulin-folding protein; involved in the final step of the tubulin folding pathway. Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372876
  • ENSP00000361967
  • ENSG00000124659

Symbol
  • CFC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
transcription factor binding site profile
0.9
histone modification site profile
0.85
transcription factor
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.9   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.9   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-chaperonin tubulin folding pathway
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-chaperonin tubulin folding pathway
Protein folding
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (56)
1 – 10 of 56
COG3
Tbio
Novelty: 0.06121869
p_int: 0.999915017
p_ni: 0.000084955
p_wrong: 2.9e-8
Score: 0.28
Data Source: BioPlex,STRINGDB
TBCD
Tbio
Novelty: 0.01673453
Score: 0.992
Data Source: Reactome,STRINGDB
TBCE
Tbio
Novelty: 0.00382883
Score: 0.991
Data Source: Reactome,STRINGDB
TUBB2A
Tclin
Novelty: 0.02116297
Score: 0.963
Data Source: STRINGDB
TUBA4A
Tchem
Novelty: 0.02626744
Score: 0.932
Data Source: STRINGDB
TUBB2B
Tclin
Novelty: 0.04266415
Score: 0.919
Data Source: STRINGDB
TUBB1
Tclin
Novelty: 0.05351568
Score: 0.917
Data Source: STRINGDB
TUBB6
Tclin
Novelty: 0.08106671
Score: 0.915
Data Source: STRINGDB
TUBB4A
Tclin
Novelty: 0.00101981
Score: 0.914
Data Source: STRINGDB
TUBA1A
Tchem
Novelty: 0.0159455
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.90

PubMed score by year
PubTator Score  30.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer