Tbio TBCC Tubulin-specific chaperone C

Protein Summary

Description

Tubulin-folding protein; involved in the final step of the tubulin folding pathway. Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15814
• Q53Y43
• Q5T787

Gene Name

• TBCC

Ensembl ID

• ENST00000372876
• ENSP00000361967
• ENSG00000124659

Symbol

• CFC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
transcription factor binding site profile	0.9
histone modification site profile	0.85
transcription factor	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Chaperone / Tubulin-specific Chaperone C

DTO Classes

Protein / Chaperone / Tubulin-specific Chaperone C

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.55   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 285   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.55   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0