Tbio TBCE Tubulin-specific chaperone E

Protein Summary

Description

Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15813
• A8K8C2
• B7Z3P1

Gene Name

• TBCE

Ensembl ID

• ENST00000406207
• ENSP00000384571
• ENSG00000284770
• ENST00000543662
• ENSP00000439170
• ENST00000642610
• ENSP00000494796

Symbol

• HRD
• KCS
• KCS1
• pac2
• PEAMO

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
transcription factor binding site profile	0.84
hub protein	0.67
cell line	0.63
disease perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Chaperone / Tubulin-specific Chaperone E

DTO Classes

Protein / Chaperone / Tubulin-specific Chaperone E

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.31   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.31   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0