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Tbio
TBCE
Tubulin-specific chaperone E

Protein Classes
Protein Summary
Description
Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network. Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406207
  • ENSP00000384571
  • ENSG00000284770
  • ENST00000543662
  • ENSP00000439170
  • ENST00000642610
  • ENSP00000494796

Symbol
  • HRD
  • KCS
  • KCS1
  • pac2
  • PEAMO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.84
hub protein
0.67
cell line
0.63
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.87   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.87   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
87.3
sex hormone-binding globulin measurement
5
2
5
80.3
monocyte percentage of leukocytes
1
1
1
68.3
self reported educational attainment
1
1
1
66.8
3
2
2
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
87.3
sex hormone-binding globulin measurement
5
80.3
monocyte percentage of leukocytes
1
68.3
self reported educational attainment
1
66.8
2
1
52.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tubulin folding cofactor E
711476
Mouse
MGI:1917680
70430
Rat
RGD:1305533
361255
Dog
tubulin folding cofactor E
VGNC:47157
479197
Cow
tubulin folding cofactor E
VGNC:35653
505066
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tubulin folding cofactor E
Mouse
Rat
Dog
tubulin folding cofactor E
Cow
tubulin folding cofactor E
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15813-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-chaperonin tubulin folding pathway
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-chaperonin tubulin folding pathway
Protein folding
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (93)
1 – 10 of 93
BHMT2
Tchem
Family:  Enzyme
Novelty:  0.07713739
p_int:  0.999998872
p_ni:  0.000001128
Score:  0.467
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999966517
p_ni:  0.00003348
p_wrong:  2e-9
Data Source:  BioPlex
SFTA2
Tdark
Novelty:  0.24469271
p_int:  0.999740266
p_ni:  0.000259731
p_wrong:  3e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.999359896
p_ni:  0.000640104
Data Source:  BioPlex
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999179445
p_ni:  0.000820555
Data Source:  BioPlex
DNAJB3
Tdark
p_int:  0.998867641
p_ni:  0.001130573
p_wrong:  0.000001786
Data Source:  BioPlex
SERBP1
Tbio
Novelty:  0.03271429
p_int:  0.998616923
p_ni:  0.001382919
p_wrong:  1.57e-7
Score:  0.636
Data Source:  BioPlex,STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.998407568
p_ni:  0.001592397
p_wrong:  3.5e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.998234822
p_ni:  0.0016298
p_wrong:  0.000135377
Data Source:  BioPlex
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.991578983
p_ni:  0.00841359
p_wrong:  0.000007428
Data Source:  BioPlex
Publication Statistics
PubMed Score  101.87

PubMed score by year
PubTator Score  45.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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