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Tbio
ITSN1
Intersectin-1

Protein Summary
Description
Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple tra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381291
  • ENSP00000370691
  • ENSG00000205726
  • ENST00000381318
  • ENSP00000370719
  • ENST00000399338
  • ENSP00000382275
  • ENST00000399349
  • ENSP00000382286
  • ENST00000399352
  • ENSP00000382289
  • ENST00000399353
  • ENSP00000382290
  • ENST00000399367
  • ENSP00000382301

Symbol
  • ITSN
  • SH3D1A
  • ITSN
  • SH3D1A
  • SH3P17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.99
virus perturbation
0.97
transcription factor perturbation
0.91
transcription factor
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.39   (req: < 5)
View Publications
Gene RIFs: 30   (req: <= 3)
View Gene RIFs
Antibodies: 77   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.39   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
EFO_0005192
4
3
4
93.4
mean corpuscular hemoglobin concentration
EFO_0004528
2
2
2
93
red blood cell density measurement
EFO_0007978
1
1
1
76.5
self reported educational attainment
EFO_0004784
1
1
1
71.1
mean corpuscular volume
EFO_0004526
1
1
1
48.1
Items per page:
1 – 5 of 9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
EFO_0005192
4
93.4
mean corpuscular hemoglobin concentration
EFO_0004528
2
93
red blood cell density measurement
EFO_0007978
1
76.5
self reported educational attainment
EFO_0004784
1
71.1
mean corpuscular volume
EFO_0004526
1
48.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intersectin 1
VGNC:1150
473975
Macaque
intersectin 1
698606
Mouse
intersectin 1 (SH3 domain protein 1A)
MGI:1338069
16443
Rat
intersectin 1
RGD:2935
29491
Dog
intersectin 1
478409
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intersectin 1
Macaque
intersectin 1
Mouse
intersectin 1 (SH3 domain protein 1A)
Rat
intersectin 1
Dog
intersectin 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15811-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
533 targets
R-HSA-422475
Reactome
Cargo recognition for clathrin-mediated endocytosis
105 targets
R-HSA-8856825
Reactome
Cell death signalling via NRAGE, NRIF and NADE
76 targets
R-HSA-204998
Reactome
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Reactome
Death Receptor Signalling
141 targets
R-HSA-73887
Name
Explore in Pharos
Explore in Source
Axon guidance
533 targets
R-HSA-422475
Cargo recognition for clathrin-mediated endocytosis
105 targets
R-HSA-8856825
Cell death signalling via NRAGE, NRIF and NADE
76 targets
R-HSA-204998
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Death Receptor Signalling
141 targets
R-HSA-73887
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
protein-containing complex scaffold activity
Inferred from Direct Assay (IDA)
UniProtKB
proline-rich region binding
Inferred from Physical Interaction (IPI)
UniProtKB
guanyl-nucleotide exchange factor activity
Traceable Author Statement (TAS)
Reactome
Rho guanyl-nucleotide exchange factor activity
Traceable Author Statement (TAS)
Reactome
calcium ion binding
Non-traceable Author Statement (NAS)
UniProtKB
kinase activator activity
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (261)
1 – 10 of 261
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999999994
p_ni: 4e-9
p_wrong: 1e-9
Score: 0.966
Data Source: BioPlex,STRINGDB
EPS15L1
Tbio
Novelty: 0.06929299
p_int: 0.999999941
p_ni: 5.9e-8
Score: 0.978
Data Source: BioPlex,STRINGDB
AP2S1
Tbio
Novelty: 0.01931502
p_int: 0.999999813
p_ni: 1.85e-7
p_wrong: 2e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
NCKIPSD
Tbio
Novelty: 0.07453111
p_int: 0.999897281
p_ni: 0.000102485
p_wrong: 2.34e-7
Score: 0.208
Data Source: BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty: 0.23296904
p_int: 0.99871115
p_ni: 0.001288847
p_wrong: 3e-9
Score: 0.699
Data Source: BioPlex,STRINGDB
DTX3
Tbio
Family: Enzyme
Novelty: 0.06212096
p_int: 0.998517814
p_ni: 0.001482185
Score: 0.226
Data Source: BioPlex,STRINGDB
LSR
Tbio
Novelty: 0.00528058
p_int: 0.992653153
p_ni: 0.007346847
Data Source: BioPlex
GATD1
Tdark
Family: Enzyme
Novelty: 0.40291197
p_int: 0.990616694
p_ni: 0.009383306
Data Source: BioPlex
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
p_int: 0.981185565
p_ni: 0.018767145
p_wrong: 0.00004729
Data Source: BioPlex
NECAP2
Tdark
Novelty: 0.4141034
p_int: 0.97251014
p_ni: 0.027458602
p_wrong: 0.000031258
Score: 0.981
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  90.39

PubMed score by year
PubTator Score  56.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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