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Tbio
ITSN1
Intersectin-1

Protein Summary
Description
Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple tra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381291
  • ENSP00000370691
  • ENSG00000205726
  • ENST00000381318
  • ENSP00000370719
  • ENST00000399338
  • ENSP00000382275
  • ENST00000399349
  • ENSP00000382286
  • ENST00000399352
  • ENSP00000382289
  • ENST00000399353
  • ENSP00000382290
  • ENST00000399367
  • ENSP00000382301

Symbol
  • ITSN
  • SH3D1A
  • ITSN
  • SH3D1A
  • SH3P17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.99
virus perturbation
0.97
transcription factor perturbation
0.91
transcription factor
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.25   (req: < 5)
View Publications
Gene RIFs: 30   (req: <= 3)
View Gene RIFs
Antibodies: 77   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.25   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
533 targets
R-HSA-422475
Reactome
Cargo recognition for clathrin-mediated endocytosis
105 targets
R-HSA-8856825
Reactome
Cell death signalling via NRAGE, NRIF and NADE
76 targets
R-HSA-204998
Reactome
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Reactome
Death Receptor Signalling
141 targets
R-HSA-73887
Name
Explore in Pharos
Explore in Source
Axon guidance
533 targets
R-HSA-422475
Cargo recognition for clathrin-mediated endocytosis
105 targets
R-HSA-8856825
Cell death signalling via NRAGE, NRIF and NADE
76 targets
R-HSA-204998
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Death Receptor Signalling
141 targets
R-HSA-73887
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
protein-containing complex scaffold activity
Inferred from Direct Assay (IDA)
UniProtKB
proline-rich region binding
Inferred from Physical Interaction (IPI)
UniProtKB
guanyl-nucleotide exchange factor activity
Traceable Author Statement (TAS)
Reactome
Rho guanyl-nucleotide exchange factor activity
Traceable Author Statement (TAS)
Reactome
calcium ion binding
Non-traceable Author Statement (NAS)
UniProtKB
kinase activator activity
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (261)
1 – 10 of 261
AP2M1
Tbio
Novelty: 0.01240983
p_int: 0.999999994
p_ni: 4e-9
p_wrong: 1e-9
Score: 0.966
Data Source: BioPlex,STRINGDB
EPS15L1
Tbio
Novelty: 0.08281964
p_int: 0.999999941
p_ni: 5.9e-8
Score: 0.978
Data Source: BioPlex,STRINGDB
AP2S1
Tbio
Novelty: 0.03619645
p_int: 0.999999813
p_ni: 1.85e-7
p_wrong: 2e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
NCKIPSD
Tbio
Novelty: 0.08272059
p_int: 0.999897281
p_ni: 0.000102485
p_wrong: 2.34e-7
Score: 0.208
Data Source: BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty: 0.30354132
p_int: 0.99871115
p_ni: 0.001288847
p_wrong: 3e-9
Score: 0.699
Data Source: BioPlex,STRINGDB
DTX3
Tbio
Family: Enzyme
Novelty: 0.06810215
p_int: 0.998517814
p_ni: 0.001482185
Score: 0.226
Data Source: BioPlex,STRINGDB
LSR
Tbio
Novelty: 0.0032892
p_int: 0.992653153
p_ni: 0.007346847
Data Source: BioPlex
GATD1
Tdark
Family: Enzyme
Novelty: 1
p_int: 0.990616694
p_ni: 0.009383306
Data Source: BioPlex
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00071056
p_int: 0.981185565
p_ni: 0.018767145
p_wrong: 0.00004729
Data Source: BioPlex
NECAP2
Tdark
Novelty: 0.58353317
p_int: 0.97251014
p_ni: 0.027458602
p_wrong: 0.000031258
Score: 0.981
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  79.25

PubMed score by year
PubTator Score  56.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNND
1-70
GRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVV
70-140
GMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASVP
140-210
PVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFI
210-280
LAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTF
280-350
EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELE
350-420
RQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKH
420-490
QLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSL
490-560
HRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERL
560-630
KQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQE
630-700
AQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVK
700-770
GEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS
770-840
SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQG
840-910
EKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMD
910-980
SGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVF
980-1050
PSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARG
1050-1120
KKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDP
1120-1190
DWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVT
1190-1260
EIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYI
1260-1330
RFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENH
1330-1400
PDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLY
1400-1470
KAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIF
1470-1540
HISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKP
1540-1610
CRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEI
1610-1680
RVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP
1680-1721
MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDEP