Tbio ITSN1 Intersectin-1

Protein Summary

Description

Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15811
• A7Y322
• A8CTX8
• A8CTY3
• A8CTY7
• A8D7D0
• A8DCP3
• B4DTM2
• E7ERJ1
• E9PE44
• E9PG01
• E9PHV2
• O95216
• Q0PW94
• Q0PW95
• Q0PW97
• Q14BD3
• Q1ED40
• Q20BK3
• Q9UET5
• Q9UK60
• Q9UNK1
• Q9UNK2
• Q9UQ92

Gene Name

• ITSN1

Ensembl ID

• ENST00000381291
• ENSP00000370691
• ENSG00000205726
• ENST00000381318
• ENSP00000370719
• ENST00000399338
• ENSP00000382275
• ENST00000399349
• ENSP00000382286
• ENST00000399352
• ENSP00000382289
• ENST00000399353
• ENSP00000382290
• ENST00000399367
• ENSP00000382301

Symbol

• ITSN
• SH3D1A
• ITSN
• SH3D1A
• SH3P17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.99
virus perturbation	0.97
transcription factor perturbation	0.91
transcription factor	0.87

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Intersectin-1

Protein / Enzyme Modulator / G-protein Modulator / Intersectin-1

Protein / Calcium-binding Protein / Intersectin-1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Intersectin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.67   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.67   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (261)

Explore Interacting Targets

1 – 10 of 261

• See Interactions on String-DB

AP2M1

Tbio

Novelty:  0.00769368

p_int:  0.999999994

p_ni:  4e-9

p_wrong:  1e-9

Score:  0.966

Data Source:  BioPlex,STRINGDB

EPS15L1

Tbio

Novelty:  0.06929299

p_int:  0.999999941

p_ni:  5.9e-8

Score:  0.978

Data Source:  BioPlex,STRINGDB

AP2S1

Tbio

Novelty:  0.01931502

p_int:  0.999999813

p_ni:  1.85e-7

p_wrong:  2e-9

Score:  0.977

Data Source:  BioPlex,STRINGDB

NCKIPSD

Tbio

Novelty:  0.07453111

p_int:  0.999897281

p_ni:  0.000102485

p_wrong:  2.34e-7

Score:  0.208

Data Source:  BioPlex,STRINGDB

RUNDC3A

Tdark

Novelty:  0.23296904

p_int:  0.99871115

p_ni:  0.001288847

p_wrong:  3e-9

Score:  0.699

Data Source:  BioPlex,STRINGDB

DTX3

Tbio

Family:  Enzyme

Novelty:  0.06212096

p_int:  0.998517814

p_ni:  0.001482185

Score:  0.226

Data Source:  BioPlex,STRINGDB

LSR

Tbio

Novelty:  0.00528058

p_int:  0.992653153

p_ni:  0.007346847

Data Source:  BioPlex

GATD1

Tdark

Family:  Enzyme

Novelty:  0.40291197

p_int:  0.990616694

p_ni:  0.009383306

Data Source:  BioPlex

ALOX5

Tclin

Family:  Enzyme

Novelty:  0.00062988

p_int:  0.981185565

p_ni:  0.018767145

p_wrong:  0.00004729

Data Source:  BioPlex

NECAP2

Tdark

Novelty:  0.4141034

p_int:  0.97251014

p_ni:  0.027458602

p_wrong:  0.000031258

Score:  0.981

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (21)

Reactome (18)

PathwayCommons (3)

Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Death Receptor Signalling	141 targets	R-HSA-73887

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Death Receptor Signalling	141 targets	R-HSA-73887

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (6)

Components (10)

Processes (11)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
protein-containing complex scaffold activity	Inferred from Direct Assay (IDA)	UniProtKB
proline-rich region binding	Inferred from Physical Interaction (IPI)	UniProtKB
guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome
Rho guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome
calcium ion binding	Non-traceable Author Statement (NAS)	UniProtKB
kinase activator activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (25)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 25

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	4	3	4		94.3
hemoglobin measurement	EFO_0004509	4	5	6		87.9
hematocrit	EFO_0004348	4	4	7		87.3
glomerular filtration rate	EFO_0005208	6	2	5	5.7	87.2
mean corpuscular hemoglobin concentration	EFO_0004528	2	2	2		86.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 25

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	4		94.3
hemoglobin measurement	EFO_0004509	6		87.9
hematocrit	EFO_0004348	7		87.3
glomerular filtration rate	EFO_0005208	5	5.7	87.2
mean corpuscular hemoglobin concentration	EFO_0004528	2		86.3

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Cell junction
Cell projection
Coated pit
Coiled coil
Complete proteome
Cytoplasm
Endocytosis

GWAS Trait Find Similar Targets

No Header	No Header
biological sex
blood urea nitrogen measurement
body height
COVID-19
educational attainment
erythrocyte count
erythrocyte measurement
FEV/FEC ratio
glomerular filtration rate
gut microbiome measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	intersectin 1	VGNC:1150	473975
Macaque	intersectin 1		698606
Mouse	intersectin 1 (SH3 domain protein 1A)	MGI:1338069	16443
Rat	intersectin 1	RGD:2935	29491
Dog	intersectin 1		478409

Species	Name	OMA	EggNOG	Inparanoid
Chimp	intersectin 1
Macaque	intersectin 1
Mouse	intersectin 1 (SH3 domain protein 1A)
Rat	intersectin 1
Dog	intersectin 1

Publication Statistics

PubMed Score 107.67

PubMed score by year

Reset Zoom

PubTator Score 56.37

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (66)

GeneRif Annotations (30)

Items per page:

10

0 of 0

PMID	Year	Title